中文摘要：

有关细胞成分在严格的条件下复制自身的机制,还有很多谜团.协助成对染色体分离的中心体（以及其他细胞器）可在合适的时间自主复制,并且不需要DNA作为向导.这种独立性还有待一步步揭示.本文通过中心体复制和中心体周期调控方面的大量研究成果,特别是近年来的新进展,从4个方面诠释了这种“独立性”：在中心体的“独立”复制和DNA复制-遗传物质稳定控制的上游,具有总揽性的统一基础,因而虽“独立”却不“孤立”或无本;多功能的激酶Plk1等核心调控因子及相关分子复合结构协调了中心体周期和染色体/DNA周期;类似“感应开关”效应的结构形成和转变起止模式,精密地控制了中心体复制及其周期;中心体结构复制及其周期调控在有统一基础的框架内分化、适应,是以多环节、多途径过程产生特异功能体的典型例子.

英文摘要：

There are many mysteries to be solved for the mechanisms that endow the ability for cellular components to replicate themselves on strict conditions. In the cytoplasm of animals and lower plants, there is a sort of non-membranous organelles, centrosome, within the middle of Golgi complex, having obtained its name because of being close to the center of the cell. Centrosome is the inner active center during cell division and, as the microtubule organizing center, playing roles in coordinating microtubule dynamics and regulating G1/S and G2/M phase transition. In centrosomal cycle, converging of paired （mother and daughter） centrioles hinders their reduplication, the two centrioles mutually detach in telophase of the mitosis. In GI/S phase transition, a new pre-centriole structure forms nearby the mother centriole. As an organelle which aids paired chromosomes to be pulled apart, centrosomes, and other organelles, autonomously finish replication on their own time without DNA＇s guidance. This independence still remains to be further explained. This study, through a lot of fruits, especially the recent progress, in the study related to centrosome replication and centrosomal cycle, unscrambles this independence. This interpretation shows four main arguments： （i） The ＂independence＂ of centrosome replication is based on the upstream overview unity of control it shares with DNA replication-genetic material stability, so it is ＂independence＂ but not isolated or rootless. Proteins such as Plkl, Cyclins and 14-3-3 represent the consensus elements between centrosomal cycle and DNA cycle regulation, and play pivotal roles in the whole activities of cell cycle. （ii） Milti-functional core regulators, such as Plkl kinase, and relevant molecular composite structures coordinate centrosomai cycle and chromosomal/DNA cycle. The correlation between centrosome and genetic structure can be understood that, when DNA is damaged, eentrosomes will commonly amplify, and this amplification is Plkl and Separase depende