中文摘要：

目的系统评价Livin在胃癌中的表达及与临床相关性。方法从PubMed、Embase、Corchrane library、Web of science、中国生物医学文献（CBM）、万方、中国知网（CNKI）数据库检索公开发表的关于不同病理参数（年龄、性别、肿瘤直径、分化程度、淋巴转移、浸润深度）胃癌中Livin表达的文献（对被检索的文献时间无限制）,依据纳入标准和排除标准以及质量评价原则,纳入符合要求的文献,利用Rev Man 5.3软件进行Meta分析。结果共20篇文献1802例患者纳入研究。Meta分析结果显示：Livin在低分化组表达高于中高分化组（OR=0.19,95%CI 0.15~0.25,P〈0.05）;Livin在淋巴结转移组中表达高于无淋巴结转移组（OR=3.15,95%CI 2.28~4.36,P〈0.05）;Livin在浆膜以外侵犯组表达高于局限浆膜层以内侵犯组（OR=2.72,95%CI 1.80~4.10,P〈0.05）;Livin在直径超过5 cm的实体瘤患者组表达高于5 cm以下组（OR=1.62,95%CI 1.16~2.28,P〈0.05）;Livin在不同性别胃癌患者中表达差异无统计学意义（OR=1.19,95%CI 0.95~1.49,P〉0.05）;Livin在不同年龄组胃癌患者中表达差异无统计学意义（OR=1.32,95%CI 1.00~1.74,P=0.05）。结论 Livin在胃癌患者中的表达水平与肿瘤的大小、分化程度、淋巴结转移及浸润深度有明显相关性。Livin可作为评价胃癌恶性程度及进展期的指标之一。

英文摘要：

Objective To systematically assess the expression and clinical relevance of Livin in gastric cancer. Meth- ods Published studies regarding the expression of Livin in gastric cancer with different pathological parameters （age, gender, differentiation, lymph node metastasis, invasion depth, tumor diameter） were searched （no time limit on literature） from PubMed, Embase, Corchrane library, Web of science, CBM, Wanfang and CNKI. Eligible studies were selected according to the inclusion/exclusion criteria and principle of quality evaluation, and Meta-analysis was performed by RevMan 5.3 software. Results A total of 20 studies with 1802 patients were included. The results of Meta analysis showed that Livin expression levels in patients with poorly differentiation were higher than those with moderately and highly differentiation （OR=O.19, 95%CI 0.15-0.25,P 〈 0.05）. Livin expression levels in patients with lymphnode metastasis were higher than those without lymph node metastasis （0R=3.15, 95%CI 2.28-4.36, P 〈 0.05）. Livin expression levels in patients with serosa and serosa outside invasion were higher than those with only subserosa invasion （0/？=2.72, 95%CI 1.80-4.10, P 〈 0.05）. Livin expression levels in patients with tumor diameter ≥5 cm were higher than those with tumor diameter 〈5 cm （0R=1.62, 95%CI 1.16-2.28, P 〈 0.05）. Livin expression in male and female had no significant difference （OR=l.19, 95%CI 0.95-1.49, P 〉 0.05）. Livin expression in patients aged ≥60 years and aged 〈60 years had no significant difference （0R=1.32, 95%CI 1.00-1.74, P=0.05）. Conclusion Livin expression in gastric cancer is obviously related to the size of tumor, differentiation, lymph node metastasis and invasion depth. Livin can be used as an indicator for evaluation of malignant degree and progression of gastric cancer.