中文摘要：

目的：系统评价Kiss-1在结直肠患者中的表达及其临床相关性.方法：检索国内外公开发表的关于不同病理参数（年龄、性别、分化程度、淋巴转移、侵润深度、组织学类型、肿瘤部位、TNM分期）结直肠癌中Kiss-1表达的文献,依据纳入标准和排除标准,纳入符合要求的文献,利用Revman 5.3软件进行Meta分析.结果：纳入7篇文献,520例患者纳入研究.Meta分析结果显示Kiss-1在中高分化组表达要高于低分化组（OR=1.98,95%CI=1.22~3.22,P〈0.05）;Kiss-1在TNMⅠ＋Ⅱ中表达要高于TNMⅢ＋Ⅳ组（OR=5.22,95%CI=2.83~9.63,P〈0.05）;Kiss-1在无淋巴结转移组中表达要高于有淋巴结转移组（OR=0.26,95%CI=0.17~0.40,P〈0.05）;进行敏感性分析后可谨慎认为Kiss-1在局限浆膜以内组表达要高于浆膜层以外侵犯组（OR=2.03,95%CI=1.07~3.84,P〈0.05）;Kiss-1在不同性别组结直肠癌患者组织中表达无差异,（OR=0.92,95%CI=0.62~1.37,P〉0.05）;Kiss-1在60岁上下年龄组结直肠癌患者中表达无差异（OR=0.86,95%CI=0.48~1.54,P〉0.05）;Kiss-1在结肠与直肠癌患者组织中表达无差异（OR=0.98,95%CI=0.42~2.25,P〉0.05）;Kiss-1在粘液与非粘液性结直肠癌患者中表达无差异（OR=0.74,95%CI=0.20~2.69,P〉0.05）;结论：Kiss-1在结直肠癌的表达水平与肿瘤的分化程度、淋巴结转移及TNM分期有相关性,Kiss-1有望作为评价结直肠癌恶性程度及进展期的指标之一.

英文摘要：

AIM： To systematically assess the expression and clinical relevance of Kiss-1 in colorectal cancer. METHODS：Publicly published domestic studies regarding the expression of Kiss-1 in different parameters（ age, gender, differentiation,lymph node metastasis,invasion depth,histological type,tumor site,TNM stage） of colorectal cancer were searched. The eligible studies were selected based on the inclusion and exclusion criteria,and meta-analysis was performed by Rev Man 5. 3 software.RESULTS： A total of 7 studies with 520 patients were included.Results of Meta- analysis for different degree of differentiation showed Kiss-1 expression in moderately and highly differentiation group was higher than poorly differentiation group（ OR = 1. 98,95% CI = 1.22 ~ 3.22,P0.05）; Kiss-1 expression in TNM Ⅰ＋Ⅱgroup was higher than TNM Ⅲ＋Ⅳ group（ OR = 5. 22,95% CI =2.83 ~ 9. 63,P 0. 05）; Kiss-1 expression in patients with lymph node metastasis group was higher than those no lymph node metastasis group（ OR = 0. 26,95% CI = 0. 17 ~ 0. 40,P 0. 05）; It can be carefully considered that Kiss-1 expression in patients with subserosa group was higher than serosa and serosa outside group after sensitivity analysis（ OR = 2. 03,95% CI = 1. 07 ~ 3. 84,P 0.05）; Kiss-1 expression in different gender groups has no difference（ OR = 0.92,95% CI = 0.62 ~ 1.37,P 0.05）; Kiss-1 expression in patients 60 years of age and those ≤60 years of age has no difference（ OR = 0.86,95% CI = 0.48 ~ 1.54,P 0.05）; Kiss-1 expression in patients with colon and rectal cancer tissue has no difference（ OR = 0.98,95% CI = 0.42 ~ 2.25,P0.05）; Kiss-1 in the mucinous carcinoma group and none-mucinous carcinoma group has no significant difference（ OR = 0.74,95% CI = 0.20 ~ 2.69,P 0. 05）. CONCLUSION： Kiss-1 can be used as a good indicator of malignant degree and progression of colorectal cancer.