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无种子法纳米金棒的制备及其对肿瘤细胞光热治疗效应研究
  • ISSN号：1000-6818
  • 期刊名称：《物理化学学报》
  • 时间：0
  • 分类：O644[理学—物理化学;理学—化学] O614[理学—无机化学;理学—化学]
  • 作者机构：[1]扬州大学化学化工学院,江苏扬州225002, [2]国家纳米科学中心纳米生物效应与安全性重点实验室,北京100190
  • 相关基金：国家自然科学基金（21261130090,21073047）和中国科学院先导科技专项（XDA09030303）资助项目
作者： 王新环[1,2], 韩秋森[2], 李婧影, 杨蓉[2], 刁国旺[1], 王琛[2]
关键词： 纳米金棒, 等离子共振吸收, 生物相容性, 表面修饰, 热疗, Gold nanorod, Plasmon resonance absorption, Biocompatibility, Surface functionalization, Hyperthermia
中文摘要：

采用简便快捷的无种子法一步完成了纳米金棒的制备。通过改变实验条件可以调控纳米金棒的吸收峰从可见到近红外转移。将巯基聚乙二醇（PEG-SH）置换金棒表面的十六烷基三甲基溴化铵（CTAB）分子，大大提高了金棒的生物相容性。制备的纳米金棒在近红外（NIR）光照射下对肿瘤细胞有很好的杀伤效果。研究结果为纳米金棒用于抗肿瘤治疗提供了实验基础。

英文摘要：

We report the synthesis of gold nanorods with a simple and efficient seedless method. By changing the experimental conditions, the longitudinal absorption peak of the gold nanorods can be shifted from the visible to the near-infrared region. Mercaptopolyethylene glycol （PEG-SH） was then used to substitute cetyltrimethyl ammonium bromide （CTAB） to improve the biocompatibility of the gold nanorods. A strong inhibition of cancer cellgrowth was observed with the modified gold nanorods under near-infrared （NIR） light irradiation. Our results wil be helpful for the potential applications of gold nanorods in clinical photo-thermal cancer therapy.

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期刊信息
  • 《物理化学学报》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:北京大学化学与分子工程学院承办
  • 主编：刘忠范
  • 地址：北京大学化学楼
  • 邮编：100871
  • 邮箱：whxb@pku.edu.cn
  • 电话：010-62751724
  • 国际标准刊号：ISSN：1000-6818
  • 国内统一刊号：ISSN：11-1892/O6
  • 邮发代号:82-163
  • 获奖情况:
  • 中文核心期刊
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘（网络版）,荷兰文摘与引文数据库,美国科学引文索引（扩展库）,英国科学文摘数据库,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,英国英国皇家化学学会文摘,中国北大核心期刊（2000版）
  • 被引量:24781