中文摘要：

一种表面电浆子回声(SPR ) 技术作为一个联机屏蔽方法被开发为肽 NH2-Cys-Thr-Trp-Trp-COOH (CW-4 ) 识别有效吸附物。验证 SPR 技术，包含氨基酸残余的几线性聚合物作为他们的相应吸附物的模型被综合。所有线性聚合物屏蔽的 SPR 证明包含本氨基丙酸残余(PPhe ) 的线性聚合物在测试的聚合物之中为 CW-4 展出了最高的亲密关系。根据从 SPR 的屏蔽结果，包含本氨基丙酸(APhe ) 的吸附物为 CW-4 展出了最高的吸附能力。有趣的观察是在 3 吸附物上吸附的 CW-4 的数量是相当小的，尽管热量测定(ITC ) 试验的 SPR 和等温的滴定显示了在 CW-4 和三聚合物之间的相互作用的存在。运动分析用 SPR 技术执行了的 A 建议如此的现象被归功于到 CW-4/polymer 建筑群的差的稳定性；也就是说， CW-4 快速与聚合物联系，但是它也快速分裂了。联合结果建议 SPR 是一个有希望的工具为肽识别最佳的吸附物，分析贡献吸附的相互作用并且解释用聚合物模型的吸附现象。

英文摘要：

A surface plasmon resonance （SPR） technique was developed as an online screening method to identify effective adsorbents for the peptide NH2-Cys-Thr-Trp-Trp-COOH （CW-4）. To validate the SPR technique, several linear polymers containing amino acid residues were synthesized as models of their corresponding adsorbents. SPR screening of all the linear polymers demonstrated that the linear polymer containing phenylalanine residues （PPhe） exhibited the highest affinity for CW-4 among the polymers tested. In accordance with the screening results from SPR, the adsorbent containing phenylalanine （APhe） exhibited the highest adsorption capacity for CW-4. An interesting observation was that the amounts of CW-4 adsorbed on 3 adsorbents were quite small, even though both SPR and isothermal titration calorimetry （ITC） experiments indicated the presence of interactions between CW-4 and the three polymers. A kinetic analysis performed using SPR technology suggested such a phenomenon was ascribed to the poor stability of the CW-4/polymer complexes; that is, CW-4 associates with the polymers quickly, but it also dissociated quickly. The combined results suggested that SPR was a promising tool to identify the optimal adsorbent for peptides, analyze the interactions contributing to adsorption and explain adsorption phenomena using polymer models.