欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
通过多步表面改性方法制备了血液相容性好的聚氨酯材料．以PEG为间隔基将ε-赖氨酸通过Schiff碱反应和进一步的还原反应连接于聚氨酯表面．该表面的水接触角和XPS结果表明，PEG和ε-赖氨酸成功接枝．用蛋白质吸附和血栓溶解实验对材料的血液相容性进行了研究．蛋白质吸附结果表明，相对于改性前的聚氨酯，ε-赖氨酸改性后的表面能减少纤维蛋白原的吸附量近80％．血栓溶解测试结果显示，ε-赖氨酸改性后的表面能够在13min内使初生的血栓溶解．这些结果证实，改性后的表面不仅能抑制非特异性蛋白质的吸附．而且在测试条件下能溶解初生的血栓。
英文摘要：
A blood-compatible polyurethane surface was prepared by multiply steps surface modification.ε-Lysine was conjugated to polyurethane surface through PEG spacer via Schiff-base and reduce reaction. The results of water contact angle and XPS measurements suggest that both PEG and lysine are immobilized to the surface successfully. Protein adsorption and plasma clot lysis measurements were performed to investigate the bloodcompatibility of the modified surface. Comparing with the unmodified surface, ε-lysine modified surface reduced fibrinogen adsorption by 80%. It was shown in clot lysis experiment that the ε-lysine modified surface could break down the incipient fibrinous clot within 13 min. The results demonstrate that ε-lysine modified surface not only suppress non-specific protein adsorption, but also degrade fibrin in an evolving clot.
同期刊论文项目
同项目期刊论文
Adsorbents with high selectivity for uremic middle molecular peptides containing Asp-Phe-Leu-Ala-Glu
Preparative separation of four individual flavonoids in Scutellaria barbata D. Don based on high sel
Application of surface plasmon resonance in screening adsorbents and explaining adsorption phenomena
Qualitative and quantitative relationships between affinity constants from model study and real adso
Colorimetric detection of bis-phosphorylated peptides using zinc(ii) dipicolylamine-appended gold na
Rapid and efficient screening of adsorbent for oligopeptide using molecular docking and isothermal t
High selective purification of flavonoids from natural plants based on polymeric adsorbent with hydr
Preparation and recognition study on the peptides in aqueous media of poly(pyridine derivative-co-ac
Separation of sanguinarine and chelerythrine in Macleaya cordata (Willd) R. Br based on methyl acryl
Synthesis of high selectivity polymeric adsorbent and its application on the separation of ginkgo fl
期刊信息
位置：