中文摘要：

目的：分析结核患者Thl7应答与CDl9＋CD5＋CDld＋B细胞频率的相关性。方法：应用流式细胞术检测健康对照、结核潜伏感染者、结核患者外周血中Thl7应答水平及CDl9＋CD5＋CDld＋B细胞频率。结果：结核患者Thl7应答水平为（3．34±1．35）％，显著低于健康对照（4．60±1．56）％（q=6．56，P〈0．001）和结核茵潜伏感染者（4．13±1．91）％（q=2．96，P〈0．05）；结核患者CDl9＋CD5＋CDld＋B细胞频率为（28．29±11．03）％，显著高于健康对照（21．05±10．86）％（q=3．69，P〈0．05）和潜伏感染者（20．46±9．88）％（q=3．59，P〈0．05）；结核患者r11117应答与CDl9＋CD5＋CDld＋B细胞频率呈负相关性（r=一0．4673，P〈0．05）。结论：活动性结核病患者Thl7细胞应答受抑制．这种抑制可能与CDl9＋CD5＋CDld’B细胞频率的增多有关。

英文摘要：

Objective To investigate the correlation between the frequencies of Thl7 cells and CD19 CDldCD5 B cells in peripheral blood of tuberculosis （TB） patients. Methods The frequencies of Thl7 cells and CD19CDldCD5 B cells in the healthy controls,latent tuberculosis infection and the TB patients were detected by flow cytometry assay. Results The frequency of Thl7 cells in patients with active tuberculosis was （3.34 ＋ 1.35）% ,which was significantly lower than that in the healthy donors （HD） （4.60 _＋ 1.56%） （q = 6.56,P 〈 0.001） and than that in individuals with latent tuberculosis infection（LTBI） （4.13 1.91）%（q = 2.96,P 〈 0.05）, respectively. The proportion of CD19＋CDldCD5B cells in TB patients was （28.29 _＋ 11.03）%,which was much higher than that in HDs（21.05 10.86）%（q = 3.69,P 〈 0.05） and than that in LTBIs（20.46 9.88）%（q = 3.59,P 〈 0.05）; Increasing CD19 CDldCD5 B cells in TB patients inversely correlated with Thl7 response in patients with TB. Conclusion Thl7 response in patients with tuberculosis was suppressived and the suppressive Thl7 response in patients with tuberculosis may be associated with increasing CD19CDldCD5 B cells.