中文摘要：

目的探讨整合素α2（ITGA2）基因C807T多态性与脑梗死的关系及其对血脂、载脂蛋白水平的影响。方法选择住院的脑梗死患者150例为脑梗死组，另选健康体检者170例为对照组。应用PCR—RFLP方法检测两组ITGA2的基因型；同时按常规方法测定血脂和载脂蛋白水平。结果与对照组比较，脑梗死组患者TC、TG、LDL—C水平明显升高（P〈0．05），ITGA2基因C807T多态性在两组人群中的分布差异有统计学意义（P〈0．05），T等位基因携带者患脑梗死的风险是C等位基因的1．690倍（OR=1．690，95％CI：1．219～2．341），携带T等位基因的脑梗死个体TC水平明显高于不携带者（P〈0．05）。结论ITGA2基因C807T多态性与脑梗死发病有相关性，其中T等住基因可能是脑梗死的遗传易感基因；ITGA2基因C807T多态性可能通过影响血脂水平而影响脑梗死的发生。

英文摘要：

Objective To study the relationship of integrin alpha-2（ITGA2） gene C807T polymorphism with cerebral infarction and the effect of integrin gene polymorphism on plasma lipid and lipoprotein levels. Methods 150 patients with cerebral infarction were selected as the cerebral infarction group and 170 healthy subjects as the control group. Polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） was used to detect the genotype of the ITGA2 gene in the two groups. The plasma lipid and lipoprotein levels were measured by routine method. Results Compared with the control group,plasma total cholesterol,triglyceride and low density lipoprotein-cholesterol（LDL-C） levels in the patients with cerebral infarction were significantly higher （P 〈 0.05）. The difference of distribution of ITGA2 gene C807T polymorphism between the 2 groups was statistically significant （P 〈 0.05）. The relative risk for cerebral infarction in subjects carrying T allele was 1. 690 times of that in the C allele carriers （OR = 1. 690,95 % CI： 1. 219--2.341）. The level of plasma lipid in cerebral infarction patients carrying T allele was significantly higher than that in not carriers （P 〈 0.05）. Conclusions ITGA2 gene C807T polymorphism was associated with cerebral infarction. 807 T allele may be the genetic susceptibility gene for cerebral infarction. ITGA2 gene C807T polymorphism may affect cerebral infarction through plasma lipid and lipoprotein levels.