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A new sesquiterpene lactone from the fruits of Illicium henryi
  • ISSN号:1875-5364
  • 期刊名称:Chinese Journal of Natural Medicines
  • 时间:2014.6
  • 页码:477-480
  • 分类:R284[医药卫生—中药学;医药卫生—中医学]
  • 作者机构:[1]School of Pharmaceutical Science, Zhengzhou University, Zhengzhou 450001, China, [2]Henan Key laboratory for Pharmacology of Liver Disease, Academy of Medical and Pharmaceutical Science, Zhengzhou Uni- versity, Zhengzhou 450052, China, [3]School of Pharmaceutical Science, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, China
  • 相关基金:This project was supported by the National Natural Science Foundation of China (No. 81172961) and the Exter- nal Cooperation Program of the Chinese Academy of Sciences (P2009- KF10).; The authors are grateful to Dr. ZHAO Bing, School of Pharmaceutical Science, Zhengzhou University, for the mea- surements of all spectra.
  • 相关项目:八角属化学成分及抗乙型肝炎病毒(HBV)活性研究
中文摘要:

AIM: To study the chemical constituents of the fruits of Illicium henryi. METHOD: Chromatographic separations on silica gel, Sephadex LH-20 gel and MCI gel were used to isolate the compounds. The structures were elucidated based on extensive spectroscopic data analyses. RESULTS: Seven compounds were obtained and their structures were identified as 10-benzoyl-cycloparvifloralone(1), cycloparvifloralone(2), 2α-hydroxycycloparviforalone(3), henrylactone B(4), merrillianone(5), henrylactone C(6) and 7, 14-ortholactone-3-hydroxyfloridanolide(7). CONCLUSION: Compound 1 is a new sesquiterpene lactone. The tested compounds showed weak anti-HBV activities on HBV surface antigen(HBsAg) secretion and HBV e antigen(HBeAg) secretion using Hep G2.2.15 cell line.

英文摘要:

AIM: To study the chemical constituents of the fruits oflllicium henryi. METHOD: Chromatographic separations on silica gel, Sephadex LH-20 gel and MCI gel were used to isolate the compounds. The structures were elucidated based on extensive spectroscopic data analyses. RESULTS: Seven compounds were obtained and their structures were identified as 10-benzoyl-cycloparvifloralone (1), cyclopar- vifloralone (2), 2a-hydroxycycloparvifomlone (3), henl-ylactone B (4), merrillianone (5), henrylactone C (6) and 7, 14-ortholactone- 3 -hydroxyfloridanolide (7). CONCLUSION: Compound 1 is a new sesquiterpene lactone. The tested compounds showed weak anti-HBV activities on HBV surface antigen (HBsAg) secretion and HBV e antigen (HBeAg) secretion using Hep G2.2.15 cell line.

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