近年来糖尿病患病率迅速增高,已经成为严重的世界性公共卫生问题。糖尿病肾病是导致终末期肾功能衰竭的主要原因,也是糖尿病最常见的慢性并发症之一。然而,糖尿病以及糖尿病肾病的发病机制至今仍没有完全阐明。白细胞介素(IL)-17在自身免疫性疾病及炎性疾病中发挥了重要的作用。本文就IL-17在糖尿病和糖尿病肾病发病过程中的作用进行综述。
In recent years,the prevalence of diabetes has increased rapidly,and which has become a serious public health problem worldwide.Diabetic nephropathy is a major cause of end-stage renal failure,which is also one of the most common chronic complication of diabetes.However,the pathogenesis of diabetes and diabetic nephropathy has not been fully elucidated up to now.IL-17plays a key role in autoimmune disease and inflammatory disease.This article reviews the role of IL-17in the pathogenesis of diabetes and diabetic nephropathy.