中文摘要：

雌激素受体（estrogen receptor,ER）作为一种转录因子,是核受体蛋白超家族中的一员,它包括ERα和ERβ两种亚型。ERα在雄性生殖系统中广泛分布,通过配体依赖和非依赖途径对雄性生殖功能起着重要的调节作用。本文主要综述ERα的分子结构、作用方式以及其在雄性生殖系统内的分布,并通过对ERα相关的动物模型的分析,探究ERα在调控雄性生殖系统中的作用机制。

英文摘要：

Estrogen receptors（ ERs）,including two sub-types ERα and ERβ,belong to the steroid hormone superfamily of nuclear receptors. ERα distributes in the male reproductive system and plays a crucial role in the regulation of male reproduction through estrogen-dependent and-independent ways. In this article,we mainly reviewed the molecular structure,mode of action and location of ERα in the male reproductive system,and explored the mechanism of ERα in regulating the male reproductive system by analyzing different animal models of disrupted ERα.