中文摘要：

潮霉素A是一种从吸水链霉菌中发现的具有广谱生物学活性的抗生素。它在吸水链霉菌Streptomy-ces hygroscopicus NRRL 2388中的生物合成基因簇已被克隆并测序,其生物合成机制、遗传操作等方面的研究也取得了一定的进展。就潮霉素A的化学结构、生物合成基因簇的组织结构、生物合成和抗性机制等方面的研究进展进行综述。

英文摘要：

Hygromycin A is an antibiotic with broad spectrum of bioactivities found from Streptomyces hygroscopicus（Sh） NRRL 2388.The biosynthetic gene cluster of hygromycin A from Sh has been cloned and sequenced.Recent progress on its mechanism of biosynthetic pathway,genetic engineering and self-resistance mechanism were summarized in this article.