中文摘要：

动物肠道经常接触微生物而引起免疫应答,持续感染将导致胃肠疾病的发生.大量文献报道了果蝇中肠是研究肠道干细胞稳态的理想模型.本文将对果蝇肠道干细胞增殖与分化机制进行简要归纳和总结,同时对该领域的研究前景进行展望,为研究果蝇肠道内稳态提供一定的理论基础.

英文摘要：

Animal guts are constantly exposed to various ingested microbes that trigger immune response.Prolonged infection causes gastrointestinal diseases in human. The Drosophila midgut has emerged as a useful model to study the homeostasis maintained by resident intestinal stem cells（ISCs） and their progeny, creating an active research field with prolific publications. In this study, we make a summing up of relevant researches of the mechanisms on the proliferation and differentiation of ISCs, meanwhile, we look far ahead into the prospect in this field, which make the theoretical base of the research for gut homeostasis in Drosophila.