目的研究绵头雪兔子提取物对果蝇肠道免疫的影响。方法用含或不含绵头雪兔子提取物的病原微生物、致炎离子和金属离子处理果蝇,观察绵头雪兔子提取物对果蝇生存率、肠道上皮细胞死亡、黑色素瘤的产生和肠道形态学变化等的影响。结果喂食绵头雪兔子提取物的果蝇可以抵抗真菌白僵菌对肠道的感染,缓解SDS、NaCl和KAl(SO4)2诱发的炎症损伤,主要表现为提高果蝇的生存率、减少肠道上皮细胞的死亡和对肠道壁的保护作用等。结论绵头雪兔子提取物对果蝇的真菌感染和炎症损伤具有一定的抵御能力。
AIM To investigate the effect of Saussurea laniceps extracts on gut immunity of fruit flies (Dro sophila melanogaster). METHORDS Fruit flies treated with pathogenic microorganisms, inflammatory irons and metal iron were fed with and without Saussurea laniceps extracts. Their survival rates, intestinal epithelial cell death, melanoma formation and the intestinal morphological changes were observed. RESULTS Saussurea lani ceps extracts could help protect fruit flies from Beauveria bassiana infection and attenuate the inflammatory damage caused by SDS, NaC1 or KA1 ( SO4 ) 2. The survival rate of fruit flies greatly increased and intestinal epithelium cell death significantly reduced while intestinal wall was intact. CONCLUSION Saussurea laniceps extracts could en hance the resistance of D. melanogaster to fungal infection and inflammatory injury.