中文摘要：

目的：研究腺苷酸激活的蛋激酶α2亚基（AMPKα2）基因区的7个标签单核苷酸多态性位点（SNP）及其组成的单体型与有氧耐力训练前后心脏结构和功能敏感性指标变化之间的相关性,探讨其作为有氧耐力训练敏感性分子标记的可行性。方法：对102名中国北方汉族青年进行为期18周的有氧耐力训练,测定训练前后安静时、不同负荷状态下（50 W、100 W、150 W）以及恢复期的心脏结构和功能相关指标。采用MALDI-TOF MS方法解析受试者基因组DNA多态位点基因型,分析训练前后相关指标的变化与基因型之间的关联性。结果：1）rs1418442、rs11206889以及部分单体型与心脏结构指标室间隔舒张末厚度（IVSD）和左心室质量指数（LVMI）的训练敏感性相关联;2）部分单体型与心脏功能指标150 W负荷下每搏输出量指数（SVI）的训练敏感性相关联。结论：AMPKα2基因的部分基因型或单体型可以作为中国北方汉族人群心脏对耐力训练敏感的分子标记。

英文摘要：

Objective：In this paper,in order to screen the sensitivity molecular markers of aerobic training,the association of 7 SNP and the haplotypes in AMPKα2 region with response to left ventricular structural and functional parameters after aerobic endurance training were researched.Methods：18-weeks aerobic endurance training was completed by 102 health male young people.Parameters of left ventricular structures and functions were measured on resting,incremental exercise（50W,100W and 150W） and recovery state before and after training.The genetype were determined by MALDI-TOF.The relativity between changes of parameters and genetypes were analyzed.Results：1） rs1418442,rs11206889 and a certain haplotypes are responded to the sensitivity of IVSD and LVMI.2） Certain haplotypes are responded to the sensitivity of SVI/150W.Conclusion：rs1418442,rs11206889 and certain genetypes of AMPKα2 can be served as sensitivity molecular markers of heart responded to endurance training of northern Han Nationality Chinese.