中文摘要：

随着抗生素在饲料中滥用导致的问题日趋严重，抗菌肽因其分子量小、抗菌谱广、抗菌活性高、耐热性强、不易产生抗药性、对高等生物正常细胞无毒害等优点已成为安全绿色抗生素添加剂替代品的理想选择。随着对抗菌肽结构、功能与杀菌机理研究的深入，人们开始尝试通过各种生物学手段设计杀菌活力更强、抗茵谱更广的杂合抗茵肽。从杂合抗茵肽的设计、生物学活性以及未来的研究方向等方面综述了杂合抗菌肽的研究进展。

英文摘要：

With the over-use of antibiotic in feed, antimicrobial peptides （AMPs） attract more and more attention as new medicine because of small molecular, broad antimicrobial spectrum, high activity, heat tolerance, drug resistance and safe. With the deep research in structure, function and antimicrobial mechanism of AMPs, people try to design new hybrid antimicrobial peptides which possess higher antimicrobial activity and broader spectrum. The paper summarizes the progress of hybrid AMPs from the following aspects ： design, biology activity and the future focus.