EGCG和维生素E对孕前期铅暴露仔鼠学习记忆能力的影响
- ISSN号:1671-6825
- 期刊名称:《郑州大学学报:医学版》
- 时间:0
- 分类:R[医药卫生]
- 作者机构:[1]College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China, [2]College of Food Science and Technology, Henan Agriculture University, Zhengzhou 450002, Henan, China, [3]Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers New Jersey Medical School, New Jersey 07103-2714, Newark, USA
- 相关基金:This research was supported by the National Natural Science Foundation of China (NSFC), No. 31201878, 81172716, and U1204804; Post Doctoral Foundation of China, No. 2015M572109; and Post Doctoral Fund of Henan province, No. 2014049.
中文摘要:
铅暴露是为象 Alzheimers 疾病(广告) 那样的 neurodegenerative 疾病的一个已知的潜在的风险因素。在大脑开发的批评阶段期间带的暴露在以后的生活与智力迟钝和 hypophrenia 被连接了。这研究被瞄准在他们的后代的马头鱼尾的怪兽在降级胰岛素的酶(IDE ) 和神经生长因素(NGF ) 的表达式上调查怀孕鼠标的铅暴露的效果。血样品从尾巴静脉被收集,并且在 anesthetizing 以后小狗,大脑在出生后的白天被切除 21。铅集中被石墨炉子决定 IDE 和 NGF 的原子吸收 spectrophotometry,和表情被 immunohistochemistry 并且西方的弄污决定。结果证明在在小狗的马头鱼尾的怪兽的 IDE 和 NGF 表示的减小可能与学习和记忆和痴呆在怀孕和哺乳期间由母亲的铅暴露导致了的缺陷被联系。
英文摘要:
Lead exposure is a known potential risk factor for neurodegenerative diseases such as Alzheimer’s disease (AD). Exposure to lead during the critical phase of brain development has been linked with mental retardation and hypophrenia in later life.