中文摘要：

目的 分析急性缺血性脑卒中患者症状侧颈动脉粥样硬化病变特征与扩散加权成像（DWI）证实的急性脑梗死（ACI）发生及严重程度的关联性.方法 入组发生单侧肢体症状（颈内动脉供血区）的ACI患者103例,均在发病后1周内行颈动脉磁共振黑血成像（MR-BBI）及头颅常规MRI,测得症状侧颈动脉粥样硬化病变参数（管腔狭窄率、斑块负荷和成分）和相应供血区ACI病灶分布及大小,借此分析症状侧颈动脉斑块特征与ACI发生、大小的关联程度.结果 研究发现,症状侧颈动脉管壁体积标准化指数（PWV）及富脂质核（LRNC）含量是同侧供血区ACI病灶发生及大小的独立危险因素（校正管腔狭窄和临床因素前后,P〈0.05）.结论 ACI发生及大小与同侧供血颈动脉的斑块易损特征（高斑块负荷和大LRNC）相关联.MR-BBI能细致化评估斑块易损特征,有利于临床分层急性缺血性脑卒中的风险性及严重程度.

英文摘要：

Objective To determine the association of symptomatic side carotid atherosclerotic plaque characteristics with the presence and severity of acute cerebral infarct （ACI）lesions which analyzed by diffusion weighted imaging （DWI）.Methods 103 pa-tients suffered from unilateral limb symptoms （internal carotid artery territorial）with acute ischemic stroke were enrolled in our study.Each patient received carotid magnetic resonance black blood imaging（MR-BBI）and brain MRI within 1 week after onset of the symptoms.The carotid atherosclerotic lesion variables （luminal stenosis,plaque burden and components）and corresponding ACI lesion size were analyzed to evaluate the correlation between carotid plaque characteristics and ACI presence and size.Results Our research found that percent wall volume（PWV）and the lipid rich necrotic core（LRNC）size were significantly associated with ipsilateral ACI presence and size before and after adjustment for stenosis or clinical factors in patients with carotid plaque （P〈0.05）.Conclusion Carotid plaque vulnerable characteristics （large plaque burden and large LRNC）are associated with the incidence and size of ACI. Our findings indicated that characterizing atherosclerotic plaque with MR-BBI might be useful for stratification of plaque risk and pre-diction of ACI severity.