中文摘要：

目的应用3．0T磁共振研究急性脑缺血患者颈动脉和患侧大脑中动脉的斑块负荷，探究两者之间的关系。方法50例经临床和MRI证实为急性前循环缺血的患者在发病1周内行颈动脉和患侧大脑中动脉磁共振多序列检查，测得各血管的管腔面积（LA）、管壁面积（WA）、血管总面积（TVA），并计算出管壁标准化指数（NWI=WA／TVA）。结果①同一患者两侧的颈动脉NwJ之间差异无统计学意义（P〉0．05）；②大脑中动脉M1段的NWI（0．62±0．07）比同侧颈动脉的NWI（0．36±0．06）显著增高（P〈0．01）；③同侧颈动脉与大脑中动脉M1段的NwJ间存在显著的相关性（左侧r=0．89，P〈0．001；右侧r=0．79，P〈0．001）。结论动脉粥样硬化是一种系统性病变，可以同时累及多个血管床，而急性脑缺血患者以大脑中动脉斑块负荷增加更为显著。

英文摘要：

Objective To investigate the correlation of the plaque burden between carotid artery and middle cerebral artery （MCA） by 3.0T MR imaging. Methods 50 patients with acute anterior circulation stroke determined by MRI underwent carotid artery and MCA MR vessel wall imaging on a Philips Achieva 3.0 T scanner within 1 week after stroke onset. The lumen area （LA）, wall area （WA）, total vessel area （TVA） and the normalized wall index （NWI） of carotid arteries and of M1 segment of MCAs were measured. Results No significant difference of carotid plaque burden was found between both sides （ P〉0.05）. For M1 segment of MCA, the plaque burden was much higher than that of carotid artery （ P 〈0.01）. In addition, correlation analysis revealed that carotid mean NWI was significantly correlated with those of MCA. In contrast, there was no significant correlation between carotid and MCA TVA and WA. Conclusion Atherosclerosis is a systemic disease and frequently occurs in multiple vascular beds. In acute stroke patients, the plaque burden of M1 segment of MCA is proved to be more significant.