中文摘要：

骨关节病（osteoarthritis，OA）常发于中老年人群，是一种慢性致残性疾病，主要病理特点是关节软骨细胞、细胞外基质、软骨下骨合成和降解过程的动态失衡。OA的发生发展与多种因素有关，文中将对α2巨球蛋白（α2-macroglobulins，α2-M）和聚蛋白多糖酶（a disintegrin and metallo-proteinase with throm-bospondinmotifs, ADAMTS ）的结构、功能及两者的相互关系在OA发生发展中的作用机制进行综述。

英文摘要：

Osteoarthritis is a chronic disabling disease that tends to occur in middle-aged and elderly population, the main pathological characteristics are the dynamic imbalance between the synthesis and degradation of articular chondroeytes, extracellnlar matrix and subchondral bone. The occurrence and development is related to many factors. This article reviews the structure, the function and the interaction between α2-macroglobulins and a disintegrin and metallo-proteinase with throm-bospondin motifs in the development of osteoarthrifis.