中文摘要：

骨关节炎（0A）又称为退行性骨关节病，是中老年人常见的慢性病、多发病。OA患者关节疼痛、僵硬、肿大、畸形及功能障碍，严重影响患者生活质量。大骨节病（KBD）是一种以关节软骨变性坏死为主要特征的地方性疾病，发展到晚期成为典型的OA，而KBD和OA又有所不同。骨保护素（OPG）胰岛素样生长因子（IGF）-1共同参与了骨的生长、修复、改建。以下对OA临床表现、病理改变，OPG和IGF-1在OA骨重建中的作用的现状及发展进行综述。

英文摘要：

Osteoarthritis （OA） is a kind of chronic and frequently-occurring disease in the elderly. It is also called degenerative disease. Pain, stiffness, swelling, deformity and dysfunction of joints are the main clinical manifestations, which seriously affect the quality of life. Kaschin-Beck Disease （KBD） is a kind of endemic diseases; its main feature is cartilage degeneration and necrosis. Although KBD becomes a typical OA in late stage, it is different from OA. Osteoprotegerin （OPG） and insulin-like growth factor （IGF）-1 participate in the bone growth, repair, and alteration. In this paper, we summarized clinical manifestations and pathological changes of OA, and reviewed the current situation and development of OPG and IGF-1 in OA bone remodeling.