中文摘要：

以（取代）水杨醛、间（对）羧基苯胺和氨基甲酰肼为原料,分别采用冰浴法合成了4-（二乙基氨基）水杨醛-3-羧基苯胺（3a）,4-（二乙基氨基）水杨醛-4-羧基苯胺（3b）和水杨醛-3-羧基苯胺（3c）;采用固相法合成了4-（二乙基氨基）水杨醛-氨基甲酰肼（3d）;采用水浴回流法合成了3,5-二溴水杨醛-4-羧基苯胺（3e）和2-羟基-1-萘甲醛-4-羧基苯胺（3f）,3a～3f均为新化合物,其结构经1H NMR,IR,ESI-MS和元素分析表征。研究了3a～3f对大肠杆菌、金黄色葡萄球菌及欧文氏草生杆菌的抑菌活性。结果表明：3a～3f对受试菌种均有一定的抑菌活性,其中3e的抑菌活性最好。

英文摘要：

Using（ substituted） salicylaldehyde,m（ p）-carboxyaniline and carbamoyl hydrazine as the raw materials,4-（ diethylamino） salicylaldehyde-3-carboxyaniline（ 3a）,4-（ diethylamino） salicylaldehyde-4-carboxy aniline（ 3b） and salicylaldehyde-3-carboxy-aniline（ 3c） were synthesized by the ice bath method,4-（ diethylamino） salicylaldehyde-amino acid hydrazide（ 3d） was synthesized by the solid-phase method,3,5-dibromo salicylaldehyde-4-carboxyaniline（ 3e） and 2-hydroxy-1-naphthaldehyde-4-carboxyaniline（ 3f） were synthesized by the reflux method. 3a ～ 3f were novel compounds.The structures were characterized by1 H NMR,IR,ESI-MS and elemental analysis. The antimicrobial activities of 3a ～ 3f against S. aureus,E. herbicola and E. coli were investigated. The results showed that 3a ～ 3f exhibited certain biological activities,and 3e was the best one.