中文摘要：

采用酯化水解两步法高效合成3-甲基-3-丁烯-1-醇（MBOH）.首先采用硅烷嫁接法制备了MCM-48嫁接SnCl2催化剂,应用于多聚甲醛、异丁烯和醋酸缩合酯化制备3-甲基-3-丁烯-1-醇醋酸酯（MB-AC）,然后MB-AC碱性水解制备MBOH,并对缩合酯化和水解反应进行工艺条件考察.结果表明,最佳缩合酯化反应条件为：2.4 g催化剂,16 g多聚甲醛,120 g异丁烯,128 g醋酸,反应温度140℃,反应时间6h.在此条件下,MB-AC的收率为55.5％,MBOH的收率为13.8％.进一步将缩合酯化反应产物碱性水解,最佳水解条件为：水解温度50℃,进料速度为60 mL/h,碱溶液质量分数为20％.在此条件下,水解收率为94.5％.酯化水解两步法制备MBOH的总收率达到65.5％.

英文摘要：

Anchoring of tin dichloride on quaternary ammonium chloride functionalized MCM-48 as a new catalyst was used to catalyze the condensation reaction of paraformaldehyde, isobutene and acetic acid to produce 3- methylbut-3-en-l-ol acetate. By using the innovative esterification-hydrolysis two-step method, 3-methylbut-3-en-1- ol was synthesized effectively. The process conditions of esterification reaction and hydrolysis reaction were investigated. The result shows that under the optimal esterification reaction condition of 2.4 g catalyst, 16 g paraformaldehyde, 120 g isobutene, 128 g acetic acid, reaction temperature 140 ℃, reaction time 6 h, the yields of 3-methylbut-3-en-l-ol acetate and 3-methylbut-3-en-l-ol are 55.5% and 13.8%. The yield of hydrolysis is 94.5% under the optimal reaction condition of reaction temperature 50 ℃, mass fraction of alkali solution 20%, feed rate of alkali solution 20 mL/h. The final yield of MOH prepared by esterification-hydrolysis two-step method reaches to 65.5%