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Research on Fuzi based on animal thermotropism behavior to discover if it has fewer "hot" characteristics without Ganjiang
  • ISSN号:1672-2124
  • 期刊名称:《中国医院用药评价与分析》
  • 时间:0
  • 分类:Q949.746.5[生物学—植物学] S811.8[农业科学—畜牧学;农业科学—畜牧兽医]
  • 作者机构:China Military Institute of Chinese Materia Medica,302 Military Hospital of China, Chengdu University of Traditional Chinese Medicine
  • 相关基金:Supported by National Natural Sciences Foundation(No. 81173571); National Basic Research Program of China (No.2007CB512607)
中文摘要:

目的将当没有 Ganjiang (根茎 Zingiberis ) ,管理了时,调查 Fuzi (根值 Aconiti Praeparata ) 是否有更少热特征。在也与 Fuzi (根值 Aconiti Praeparata ) 对待的鼠标的 thermotropism 行为的方法差别, Ganjiang (根茎 Zingiberis ) 或二的联合 intragastrically 给用动物 Thermotropism 行为监视系统被调查。水吸入体积,氧消费体积,腺苷 triphosphatase (ATPase ) 活动,全部的抗氧化剂能力(T-AOC ) 和全部的 superoxide dismutase (T 草皮) 活动在调查期间被决定。结果当 Fuzi 和 Ganjiang 一起被管理时,老鼠在他们的运动的一个温暖的盘子(留下的率) 和时间和距离上在留下了的率都显著地被减少(P < 0.05 ) 。与正常的组相比,,减小与 Fuzi 组,相比是 55.1% , 48.3% 和 44.8% ,显示 57.6% , 34.3% 和 36.0% 那冷向性显著地被增加减小是。与正常和 Fuzi 组相比, ATPase 活动和 Fuzi + Ganjiang 组的呼吸的氧消费体积显著地被增加(P < 0.05 ) ,在精力新陈代谢建议改进并且看一个热特征 Fuzi 和 Ganjiang 什么时候在一起是在场的。另外, T-AOC 和 T 草皮活动显著地被提高(P < 0.05 ) 。向冷向性趋于的老鼠的行为能被认为是有更少特征的 Fuzi 的量的思考的结论一致 w ith 一个热性质当没与 Ganjiang 使用时,哪个可以是在在肝织物的 ATPase 活动的一个变化的功能的机制。

英文摘要:

OBJECTIVE:To investigate whether Fuzi(Radix Aconiti Praeparata) has fewer "hot" characteristics when administered without Ganjiang(Rhizoma Zingiberis).METHODS:Differences in the thermotropism behaviors of mice treated either with Fuzi(Radix Aconiti Praeparata),Ganjiang(Rhizoma Zingiberis) or the combination of the two given intragastrically were investigated using the Animal Thermotropism Behavior Surveillance System.The water intake volume,oxygen consumption volume,adenosine triphosphatase(ATPase) activity,total antioxidant capacity(T-AOC) and total superoxide dismutase(T-SOD) activity were determined during the investigation.RESULTS:When Fuzi and Ganjiang were administered together,the rate at which mice remained on a warm plate("remaining rate") and the times and distances of their movement were all significantly reduced(P〈0.05).Compared with the Normal group,the reduction was 55.1%,48.3% and 44.8%,while compared with the Fuzi group,the reduction was 57.6%,34.3% and 36.0%,indicating that "cold" tropism was significantly increased.Compared with the Normal and Fuzi groups,the ATPase activity and the respiratory oxygen consumption volume of the Fuzi + Ganjiang group were significantly increased(P〈0.05),suggesting an improvement in energy metabolism and showing a "hot" characteristic when Fuzi and Ganjiang are present together.Additionally,the T-AOC and T-SOD activity were significantly enhanced(P〈0.05).CONCLUSION:The behavior of mice tending toward "cold" tropism can be regarded as a quantitative reflection of Fuzi having fewer characteristics consistent w ith a "hot" nature when not used with Ganjiang,the functional mechanism of which may be a change in the ATPase activity in liver tissue.

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期刊信息
  • 《中国医院用药评价与分析》
  • 主管单位:国家卫生和计划生育委员会
  • 主办单位:中国医药生物技术协会 中国药房杂志社
  • 主编:张相林
  • 地址:北京市西城区广义街5号广益大厦C座511室
  • 邮编:100053
  • 邮箱:Pharmacy_bj@163.com
  • 电话:010-64813551
  • 国际标准刊号:ISSN:1672-2124
  • 国内统一刊号:ISSN:11-4975/R
  • 邮发代号:82-536
  • 获奖情况:
  • 国内外数据库收录:
  • 被引量:15803