中文摘要：

目的：系统评价六味五灵片与核苷酸类似物联合治疗慢性乙型病毒性肝炎的疗效。方法：采用Cochrane系统评价方法,在维普资讯中文科技期刊数据库、中国期刊全文数据库、万方数据库、Pub Med、Cochrane等数据库中检索关于六味五灵片与核苷酸类似物联合治疗慢性乙型病毒性肝炎的随机对照试验,对照组患者单一使用恩替卡韦、阿德福韦酯、拉米夫定和替比夫定中的1种,观察组患者在对照组基础上联合应用六味五灵片;治疗检索时间为建库至2016年。由研究人员对文献进行筛选和数据提取,采用Rev Man 5.0软件进行文献荟萃（Meta）分析。结果：共纳入17篇文献,合计1 795例受试对象,其中观察组935例,对照组860例。Meta分析结果显示,与对照组比较,观察组方案可在一定程度上改善患者的临床症状,降低丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、总胆红素水平,提高丙氨酸氨基转移酶复常率,提高乙型肝炎病毒DNA、乙型肝炎病毒E抗原阴转率。结论：与单用核苷酸类似物治疗比较,六味五灵片与核苷酸类似物联合治疗慢性乙型病毒性肝炎在改善临床症状、肝功能和抗病毒方面的疗效更好。

英文摘要：

OBJECTIVE： To systematically evaluate the efficacy of Liuweiwuling tablets combined with nucleotide analogues in treatment of chronic hepatitis B. METHODS： Cochrane systemic evaluation method was adopted,VIP database,CNKI,Wangfang database,Pub Med,Cochrane were searched up from establishment to July 2016 to find the randomized controlled trials of nucleotide analogues combined with Liuweiwuling tablet in treatment of chronic hepatitis B. The control group were treated with one drug of entecavir,adefovir dipivoxil,lamivudine and telbivudine; while the observation group were additionally treated with Liuweiwuling tablets. Screening and data extraction were conducted by researchers literature,and Meta-analysis with Rev Man 5. 0. RESULTS： 17 literatures were involved including 1 795patients; among which 935 cases in observation group and 860 cases in control group. According to Meta-analysis,compared with the control group,the clinical symptoms can be improved by the regimen in observation group by reducing alanine aminotransferase,aspartate amino transferase and total bilirubin level,increasing normalization rate of alanine aminotransferase,negative rate of chronic hepatitis B DNA and hepatitis B virus E-antigen. CONCLUSIONS： Compared with the single treatment of nucleotide analogues,the efficacy of Liuweiwuling tablets combined with nucleotide analogues in treatment of chronic hepatitis B is better in improving clinical symptoms,liver function and antiviral.