中文摘要：

目的：探讨脾多肽对接受胆囊癌辅助化疗患者细胞免疫功能的影响。方法：30例胆囊癌辅助化疗患者分为治疗组（化疗＋脾多肽）和对照组（单纯化疗）,采用流式细胞术检测淋巴细胞亚群变化。结果：化疗2周期后,治疗组CD4＋T、CD8＋T细胞占淋巴细胞总数分别为（53.73±10.24）%和（18.29±5.81）%,显著高于同期对照组的（31.81±10.19）%和（10.23±5.96）%（P〈0.05）。同时,治疗组CD4＋T细胞比例较术前的（43.51±7.30）%有明显升高（P〈0.05）。治疗组和对照组之间NK细胞比例差别无统计学意义（P〉0.05）,两组间化疗毒副作用相似（P〉0.05）。结论：脾多肽可提高胆囊辅助化疗患者外周血CD4＋T、CD8＋T细胞比例,改善免疫功能。

英文摘要：

Objective：To investigate the effects of lienal polypeptide injection on cellular immunity of gallbladder cancer patients during chemotherapy. Methods ： All 30 cases of gallbladder cancer were divided into two groups ： thera- py group（ chemotherapy ＋ lienal polypeptide） and control group （chemotherapy）. The lymphocyte subsets variations were calibrated in each group via flow cytometry. Results：After two cycles of chemotherapy, the percentages of CD4 ＋ T, CD8 ＋ T cells in therapy group were much higher than those in control group （53.73 ± 10.24） % vs （31.81± 10.19） % ,P 〈 0.05 ; （ 18.29 ± 5.81 ） % vs （ 10.23 ± 5.96） %, P 〈 0.05. Simultaneously, in therapy group, the percentage of CD4 ＋ T cell was significantly raised after treatment（43.51 ±7.30） % vs （53.73 ± 10.24） % ,P 〈0.05）. No difference was observed on percentage of NK cell and side effects of chemotherapy between wo groups （ P 〉 0.05 ）. Conclusion ： Lienal polypeptide injection can improve immune by promoting the percentages of CD4 ＋ T, CD8 ＋ T cells.