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细菌σ54启动子序列分析与预测
  • ISSN号：1001-0548
  • 期刊名称：《电子科技大学学报》
  • 时间：0
  • 分类：Q61[生物学—生物物理学]
  • 作者机构：[1]电子科技大学生物信息学中心,成都610054, [2]河北联合大学基因组学与计算生物学中心,河北唐山063000
  • 相关基金：国家自然科学基金（61202256,61301260,61100092）;中央高校基本科研业务费（ZYGX2012J113,ZYGX2013J102）
作者： 丁辉[1], 邓恩泽, 陈伟[2], 林昊[1]
关键词： 细菌, 保守性, 位置权重矩阵, 启动子, bacteria, conservative, position weight matrix, promoter
中文摘要：

对实验确定的168条σ54启动子序列进行保守性分析，获得两个保守的区域-24区域和-12区域，均为最保守的功能元件。选取保守性最大的17个保守位点的三联体频数作为参数，引入伪计数构建位置权重矩阵，对168条σ54启动子进行预测，分别从编码区和汇聚非编码区共选取168条序列组成阴性集。使用Jackknife交叉验证法对模型进行检验，整体准确度达到82.0%，为σ54启动子的理论和实验研究提供新信息。

英文摘要：

By analyzing the 168 experimental-confirmed σ54 promoter sequences, two conservative regions that are -24 and-12 regions are obtained. The trimer frequency at 17 positions in these conservative regions is selected as inputting parameter. By adding pseudo-count into position weight matrix, the σ54 promoter can be predicted. The 168 negative sequences are extracted from coding regions and convergent intergenic regions. In Jackknife cross-validation, the overall accuracy reaches to 82.0%, suggesting that the model can be further used in the theoretical and experimental study ofσ54 promoter.

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期刊信息
  • 《电子科技大学学报》
  • 北大核心期刊（2011版）
  • 主管单位:国家教育部
  • 主办单位:电子科技大学
  • 主编：周小佳
  • 地址：成都市成华区建设北路二段四号
  • 邮编：610054
  • 邮箱：xuebao@uestc.edu.cn
  • 电话：028-83202308
  • 国际标准刊号：ISSN：1001-0548
  • 国内统一刊号：ISSN：51-1207/T
  • 邮发代号:62-34
  • 获奖情况:
  • 全国优秀科技期刊,第二届全国优秀科技期刊二等奖,两次获国家新闻出版署、国家教委“全国高校自然科...,中国期刊方阵双百期刊
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,美国数学评论（网络版）,德国数学文摘,荷兰文摘与引文数据库,美国工程索引,美国剑桥科学文摘,英国科学文摘数据库,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,中国北大核心期刊（2000版）
  • 被引量:12314