中文摘要：

以丁内酯为原料，通过缩合、水解、亚胺化、关环、还原、偶联、甲酰化以及脱保护等反应设计并探索了腺仆酸琥珀酸合成酶双基抑制剂类似物的合成方法，目标化合物的结构经^1HNMR和HR—ESI—MS数据进行表钲．训步生物活性测试结果表明，目标化合物在100μg／mL浓度下对油菜和稗草具有较弱的抑制活性．

英文摘要：

The adenylosuccinate synthetase （AdSS） bisubstrate hybrid inhibitor analogues 5-（4-hydroxybenzyl）-N3- [5-ethoxyearbonyl-4-（N-formylhydroxyamino）pentyl]-hydantoin benzoates containing the structural moiety of hadacidin were designed and synthesized via Claisen condensation, hydrolysis decarbosylation, imidization, acid-catalyzed ring closure, borane reduction, Mitsunobu coupling reaction, formylation and deprotection used 1,4-butyrolactone as raw materials. Their structures were characterized with IH NMR and HR-ESI-MS data. The preliminary and greenhouse test results showed that these compounds only exhibited weak inhibition against E. rusgalli and B. campestris at the concentration of 100 lag/mL.