中文摘要：

目的探讨血管性痴呆患者血脂水平与颈动脉粥样硬化程度的关系.方法选取住院确诊的血管性痴呆患者109例,行双侧颈动脉彩超检查,根据颈动脉超声检查的结果分为3组,无斑块组（22例）,稳定斑块组（55例）和不稳定斑块组（32例）,比较3组之间血脂水平;然后将所以标本再分为血脂正常组,血脂异常组,比较2组间双侧颈动脉动脉内膜中层（intima-media thickness,IMT）厚度.结果不稳定斑块组的血脂水平高于稳定斑块组和无斑块组,差异有显著统计学意义（P〈0.001）,高血脂水平组IMT厚度（1.91±0.19）mm,高于血脂水平正常组IMT厚度（1.19±0.17）mm,差异有显著统计学意义（P〈0.01）.结论颈动脉粥样硬化的程度随血脂水平的增高而加重;且血脂水平与颈动脉粥样硬化斑块的不稳定性有关,对血管性痴呆高血脂患者应尽早干预治疗,防止病情进一步加重.

英文摘要：

Objective The purpose of this study is to explore the relationship between the level of blood fat and carotid atherosclerosis in vascular dementia patients.Methods A total of 109 patients who were admitted in our hospital with definite diagnosis of vascular dementia underwent the colored ultrasonic waveinspection at bilateral carotid arteries.According to the outcome of colored ultrasonic waveinspection, these patients were divided into three groups： without plaque group（n =22）, stable plaque group（n =55） and instable plaque group（n =32）.The level of blood fat among these three groups was compared,and the patients were divided again into normal blood fat group and abnormal blood fat group.Between these two groups, bilateral IMT was compared.Results The level of blood fat in instable plaque group was markedly higher than that of stable plaque and without plaque group respectively（P〈0.001）.IMT in high level blood fat group was significantly higher than that of blood fat normal one（1.91±0.19 vs1.19±0.17,P〈0.01）.Conclusions Our results revealed that the level of blood fat gradually increased along with the continuous aggravation of the extent of carotid atherosclerosis.The level of blood fat had conclusive correlation with the instability of plaques in carotid atherosclerosis.Therefore,for hyperlipemia patients with vascular dementia, it is necessary to interference with therapeutic strategy so as to prevent the pathogenetic condition from getting exacerbation.