中文摘要：

目的探讨纳米氧化铝暴露对雄性小鼠生殖系统的影响以及可能的机制。方法 ICR种系雄性小鼠随机分成溶剂对照组（生理盐水）、10μm粒径氧化铝组（50 mg/kg）、50 nm粒径氧化铝组（50 mg/kg）和13 nm粒径氧化铝组（50 mg/kg）。每组8只,鼻腔滴注染毒,观察一般生殖损伤、生殖激素变化以及氧化应激检测。结果染毒期间各组雄鼠体重变化没有明显差异（P〉0.05）;纳米氧化铝染毒结束后雄鼠睾丸脏器指数以及精子计数都有不同程度的降低（P〈0.05）;与溶剂对照组相比其余各组血清中生殖激素都有相应的降低（P〈0.05）;与溶剂对照组相比其余各组睾丸组织中氧化应激水平都有显著的变化（P〈0.05）。结论纳米氧化铝暴露能够对雄性小鼠产生一定的生殖损伤,且这种损伤可能与其引起雄鼠生殖激素变化以及睾丸组织的氧化应激有关。

英文摘要：

Objective To observe the effect and mechanism of reproductive damage in male mice exposure to nano alumina. Methods ICR male mice were randomly divided into control group（ saline）,micron alumina group（ 50 mg / kg）,50 nm alumina group（ 50 mg / kg）and 13 nm alumina group（ 50 mg / kg）. Each group have 8 mice,the nasal drip,to observe the reproductive toxicity and reproductive hormone changes and oxidative stress. Results The body weight of male mice was not significant（ P〉0. 05） during the test in each groups; Body mass index of the testis index and sperm counts of 13 nm alumina group were significantly decreased（ P〈0. 05） compared to other groups;reproductive hormone has a corresponding decrease（ P〈0. 05） when compared to control group; the level of oxidative stress in testis show a significant change（ P〈0. 05） compare to control groups. Conclusion Male mice can be caused reproductive damage under the exposure of nano alumina,and this damage may be ralated with the change of reproductive hormones and the oxidative stress of testis.