中文摘要：

Erythrocyte tropomodulin（E-Tmod）is a capping protein at the slow-growing end of the actin filaments and regulates the length of the junctional complex in the erythrocyte membrane skeleton^[1].E-Tmod has two alternative promoters,P_E0,and P_E1,upstream of exons EO and E1,respectively.They drive the expression of two E-Tmod isoforms,E-Tmod41 and ETmod29,which play different yet coordinated roles in cytoskeleton reorganization^[2].This study aimed at investigating the expessions of the two E-Tmod isoforms response to the mechanical stresses,i.e.,shear stress and hydrostatic pressure.A cone-plate flow system and a hydrostatic pressure device were developed.Murine erythroleukemia（MEL）cells were subjected to

英文摘要：

Erythrocyte tropomodulin（E-Tmod）is a capping protein at the slow-growing end of the actin filaments and regulates the length of the junctional complex in the erythrocyte membrane skeleton[1].E-Tmod has two alternative promoters,PE0,and PE1,upstream of exons EO and E1,respectively.They drive the expression of two E-Tmod isoforms,E-Tmod41 and ETmod29,which play different yet coordinated roles in cytoskeleton reorganization[2].This study aimed at investigating the expessions of the two E-Tmod isoforms response to the mechanical stresses,i.e.,shear stress and hydrostatic pressure.A cone-plate flow system and a hydrostatic pressure device were developed.Murine erythroleukemia（MEL）cells were subjected to