中文摘要：

目的：探讨帕金森病（PD）伴轻度认知功能障碍（PD-MCI）的相关因素及临床特征，找出帕金森病伴轻度认知功能障碍的预测因子。方法：参照运动障碍协会工作组推荐的帕金森病伴轻度认知功能障碍的诊断标准，用蒙特利尔认知功能评估量表（MoCA）及帕金森病统一评定量表（Ⅰ～Ⅲ）对81例PD患者进行评估。结果：81例PD患者中47例为轻度认知功能障碍，占58％，23例无认知功能障碍，占28％；14％PD—MCI病人病程小于5年。PD．MCI组与帕金森病不伴有认知功能障碍（PD—NCI）组在文化程度、H＆Y分期、每日左旋多巴等效剂量（LEDD）上差异有统计学意义（P〈0．05）；视空间／执行功能、延迟记忆、注意力、语言、抽象能力认知域差异有统计学意义（P〈0．05）；uPDRsⅢ、姿势不稳步态障碍（PIGD）差异有统计学意K（P〈0．05）；MoCA评分与年龄（r=-0．31，P〈0．05）、H＆Y分期（r=-0．44，P〈0．05）、UPDRS—Ⅲ分数（F．0．32，P〈0．05）、UPDRS—II（r=-0．35，P〈0．05）、UPDRS—I（r=-0．40，P〈0．05）、迟缓（r=-0．38，P〈0．05）、PIGD呈负相关（r=0．31，P〈0．05），与教育程度呈正相关（r==0．30，P〈0．05）。纳入MoCA评分为因变量，年龄、教育程度、H＆Y分期、UPDRS-111分数、UPDRS—Ⅱ分数、UPDRS—1分数为自变量行多元线性回归分析，年龄（Bcoe伍cients．0．06，P〈0．05）和H＆Y分期（βcoefficients-0．80，P〈0．05）为帕金森病伴轻度认知功能障碍的预测因子；为观察uPDRSⅢ中亚项评分对认知功能的独立影响，单独纳入迟缓和PIGD评分为自变量，结果迟缓为帕金森病伴轻度认知功能障碍的预测因子（Bcoefficients．0．12，P〈0．05）。结论：MCI是PD患者中发生率较高的一种非运动症状，以视空间／执行功能、延迟记忆、注意力、语言功能障碍为主。患者的认知功能和年?

英文摘要：

Objective： To investigate the correlated factors and predictors of mild cognitive impairment in patients with Parkinson＇s disease and its clinical characters. Methods： According to the diagnostic criteria of Movement Disorder Society Task Force for Mild Cognitive Impairment in Parkinson＇s Disease, 81 PD patients were evaluated by Montreal Cognitive Assessment （MoCA）,and Unified Parkinson＇s Disease Rating Scale （ Ⅰ -Ⅲ）. Results： In 81 PD patients, 47 cases （58 %） were with mild cognitive impairment PD-MCI and 23 cases （28 %） were with no cognitive impairment（PD-NCI）. Patients （14 %） with mild impaired cognition had a disease duration of less than 5 years. There was significant difference between PD-MCI and PD-NCI group in education （P〈0.05）, H＆Y stage （P〈0.05）, the L-dopa equivalent daily dose （LEDD）（P〈0.05）; the score in PD-MCI group was significantly lower in visuospatial and executive functioning （P 〈 0.05）, delayed recall （P 〈 0.05）, attention （P 〈 0.05）, language （P 〈 0.05） and abstract （P 〈 0.05） subdomains compared with that of PD-NCI group. The difference of UPDRSⅢ and postural instability and gait difficulty （PIGD） were statistically significant in two groups （P〈0.05）. MoCA score of PD-MCI group was negatively correlated with age （r= -0.31, P〈0.05）, H＆Y stage （r=-0.44, P〈0.05）, UPDRS-Ⅲ（r=-0.32, P〈0.05）, UPDRS-Ⅱ （r=-0.35, P〈0.05）, UPDRS- I （r = -0.40, P〈0.05）, bradykinesia（r=-0.38, P=0.05） and PIGD （r=-0.31, P〈0.05）, and MoCA score of PD-MCI group was positively correlated with education （r=0.30, P〈0.05）. Including MoCA score as the dependent variable, and age, H＆Y stage, education, UPDRS-Ⅲ, UPDRS- Ⅱ, UPDRS- Ⅰ as the independent variables, PD-MCI was predicted by age （13 coefficients -0.06, P 〈0.05） and H＆Y stage （13 coefficients -0.80, P 〈0.05）. Furthermore, multiple regressions with UPDRS subscale scores were conducted to exami