位置:成果数据库 > 期刊 > 期刊详情页
抑郁症静息态下注意网络功能连接的病例对照研究
  • ISSN号:1000-6729
  • 期刊名称:中国心理卫生杂志
  • 时间:0
  • 页码:546-550
  • 分类:R749.4[医药卫生—神经病学与精神病学;医药卫生—临床医学] B842.3[哲学宗教—基础心理学;哲学宗教—心理学]
  • 作者机构:[1]南京医科大学脑科医院精神科,南京210029, [2]东南大学学习科学研究中心,南京210096, [3]东南大学临床医学院,南京210009
  • 相关基金:国家高技术研究发展计划(863计划)(2008AA02Z410);国家自然科学基金(30900356);儿童发展与学习科学教育部重点实验室开发课题(CDL5-2009-07)
  • 相关项目:基于功能核磁共振信号的抑郁症辅助诊断模型研究
中文摘要:

目的:利用功能性核磁共振成像(fMRI)技术,观察静息态下抑郁症注意网络的功能连接。方法:26例符合中国精神障碍分类与诊断标准(第三版)(CCMD-)单相抑郁症诊断标准,同时符合美国《精神障碍诊断与统计学手册》第四版(DSM—IV)重性抑郁诊断标准抑郁症住院患者及25名年龄、受教育年限匹配的健康对照者参与了静息态fMRI扫描。分别分析抑郁症患者前、后注意网络内区域相互之间低频fMRI信号波动的相关性,以观察抑郁症注意网络的功能连接。结果:与对照组相比,抑郁组双侧前扣带回与丘脑[左侧Z分:(058±0.10)vs.(0.64±0.06),P=0.012;右侧Z:(0.53±0.13)VS.(0.61±0.13),P=0.025]、双侧基底神经节与丘脑[左侧Z分:(0.66±0.07)VS.(0.70±0.05),P=0.043,右侧Z分:(0.64±0.07)vs.(0.71±0.07),P=0.002]、左侧额叶皮层与前扣带回[Z分:(0.51±0.16)VS.(0.63±0.12),P=0.003]、左侧额叶皮层与基底神经节[Z分:(0.59±0.07)VS.(0.65±0.11),P=0.029]、右侧辅助运动区与基底神经节[Z分:(O.57±0.11)vs.(0.64±0.11),P=0.024]、右侧前扣带回与辅助运动区[Z分:(0.54±0.10)vs.(0.61±0.11),P=0.043]、右侧额叶皮层与辅助运动区的功能连接减低[Z分:(0.64±0.10)vs.(0.70±0.10),P=0.028]。结论:静息态抑郁症患者注意网络的功能连接存在异常,可能与抑郁症患者认知功能损害,尤其是注意力下降有关。

英文摘要:

Objective: To explore the functional connectivity of attentional network in depressions during resting-state with functional magnetic resonance imaging (fMRI) . Methods: Twenty-six patients were selected according to the diagnostic criteria for depression of Chinese Classification and Diagnostic Criteria for Mental Disorders Third Edition ( CCMD-3 ) and the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition ( DSM- IV) . Twenty-five healthy persons were selected as controls matched for age and education. All subjects recieved the resting state fMRI scan. To observe the attentional to the function of network connectivity, the corelations of lowfrequency fMRI signal in regiong of anterior and posterior attentional networks were analyzed. Results: Compared with the controls, the regions of function connectivity of the attentional network in depressed group were decreased. The data was as follows respectively: the bilateral anterior cingnlate and thalamus [left Z: [0.58±0. 10) vs. (0.64±0.06), P=0.012; right Z: (0.53±0.13) vs. (0.61±0.13), P=0.025], the bilateral basal ganglia and thalamus [left Z: (0.66±0.07} vs. (0.70±0.05), P=0.043, rightZ: (0.64±0.07) vs. (0.71±0.07), P=0.002], theleft frontal cortex and anterior cingulated [Z: (0.51±0.16) vs. (0.63±0.12}, P=0.003], the left frontal cortex and basal ganglia [Z: (0.59±0.07) vs. (0.65±0.11), P=0. 029 ], 0. 024], 0. 0433, 0. 028 the right supplementary motor area and basal ganglia [ Z: ( 0. 57 ±0. 11 ) vs. ( 0. 64± 0. 11 ), P = the fight anterior cingulate and supplementary motor area [Z: (0. 54±0. 10) vs. (0. 61 ±0. 11 ), P = the fight frontal cortex and supplementary motor area [ Z: ( 0. 64 ± 0. 10 ) vs. ( 0. 70 ± 0. 10 ) , P = Confusion: The abnormalities of functional connectivity exist in the attentional network of depression during resting-state, which may be associated with cognitive impairment in depression, particu

同期刊论文项目
同项目期刊论文
期刊信息
  • 《中国心理卫生杂志》
  • 北大核心期刊(2011版)
  • 主管单位:中国科学技术协会
  • 主办单位:中国心理卫生协会
  • 主编:周东丰
  • 地址:北京海淀区花园北路51号2号楼506室
  • 邮编:100191
  • 邮箱:cmhj@bjmu.edu.cn
  • 电话:010-62010890
  • 国际标准刊号:ISSN:1000-6729
  • 国内统一刊号:ISSN:11-1873/R
  • 邮发代号:82-316
  • 获奖情况:
  • 中国科学技术情报研究所"中国精品科技期刊"中国...
  • 国内外数据库收录:
  • 中国中国人文社科核心期刊,中国中国科技核心期刊,中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版),中国北大核心期刊(2000版)
  • 被引量:52864