中文摘要：

目的：分析色氨酸羟化酶1（TPH1）基因A218C多态性、5-羟色胺（5-HT）2A受体基因（HTR2A）T102C多态性对抑郁症患者额叶情绪识别功能异常的影响。方法：28例抑郁症患者（患者组）及34名性别、年龄、受教育年限相匹配的健康对照（对照组）均进行情绪识别任务态下功能磁共振扫描,并以聚合酶链式反应-限制性片断长度多态性方法确定所有被试基因型,提取双侧额叶上、中、下回为感兴趣脑区,比较不同基因型两组额叶亚区激活强度的差异。结果：①喜悦面部表情识别时,TPH1AA基因型患者组右额中回激活强度较其他各组显著降低;HTR2ACC基因型患者组右额中回激活较AA、AC基因型患者组及AA、AC基因型对照组显著降低（P〈0.05）。②悲伤面部表情识别时,TPH1AA基因型患者组、对照组左额下回激活较AC、CC基因型患者组、对照组显著增强,同时AA基因型患者组右额下回激活强度较其他各组显著增强;HTR2ACC基因型患者组右额中回激活强度较TT、TC基因型患者组、TT基因型对照组显著增强,右额下回激活强度较TT、TC基因型患者组、TT、TC基因型对照组显著增强（P〈0.05）。③TPH1A218C与HTR2AT102C对右额中回正性情绪识别、右额下回负性情绪识别时激活异常存在叠加作用,同时携带TPH1AA基因型及HTR2ACC基因型患者表现出的正性激活减弱及负性激活增强最为显著（P〈0.05）。结论：抑郁症患者额叶异常具有一定的5-HT遗传学基础,5-HT系统中的不同基因能够通过共同的5-HT能作用引起情绪识别功能异常。

英文摘要：

Objective：To explore the genetic impact of tryptophan hydroxylase 1 gene（TPH1） A218C、serotonin receptor 2A gene（HTR2A） T102C on abnormal frontal lobe of depressed patients in emotion recognization. Method：28 patients with major depression and 34 healthy controls were recruited in our study,which were equal in sex,age,years of education.They all underwent functional magnetic resonance imaging（fMRI） in emotion recognition and were divided into different genotypes with the method of polymerase chain reaction and restriction fragment length polymorphism.The frontal lobe was extracted as region of interest by WFU software into six subregions to compare differences among different groups. Results：①In recognition of happy facial expression,activation of right middle frontal gyrus in patients with TPH1AA genotype was less than other five groups.Activation in patients with HTR2ACC genotype was less than patients and controls with AA or AC genotype（P0.05） .② In recognition of sad facial expression,patients and controls with TPH1AA genotype showed increased activation in left inferior frontal lobe than those with AC or CC genotype.Patients with AA genotype showed increased activation in right inferior frontal gyurs than other five groups as well.Patients with HTR2ACC genotype showed increase activation in right middle frontal gyrus than patients with TT of TC genotype and controls with TT genotype,showing increase activation in right inferior frontal gyrus than those with TT or TC genotype（P0.05） .③Superimposition of TPH1A218C and HTR2AT102C was found in abnormal function of right middle frontal gyrus when recognizing positive emotional stimuli and right inferior grontal gyrus when recognizing negative emotional stimuli（P0.05） . Conclusion：Frontal lobe in depressive disorder has the genetic basis of 5-HT to some extent Different genes in serotonin system can affect brain function through a common 5-HT feature.