中文摘要：

以邻硝基苯甲醛为起始原料，经还原、Friedlander缩合反应合成2-甲基-3-喹啉甲酸乙酯（2），2经N-溴代丁二酰亚胺（NBS）溴代得到化合物3，3再与N-取代哌嗪5a-5p发生SN2亲核取代反应，合成一系列2-（取代哌嗪-1-甲基）-3-喹啉甲酸乙酯及其衍生物6a-6p．它们的结构通过元素分析，IR，^1H NMR，^13C NMR和MS进行了鉴定和表征，并用X射线衍射法测定了化合物6n的晶体结构．

英文摘要：

2-Methyl-quinoline-3-carboxylic acid ethyl ester （2） was prepared by reduction of o-nitrobenzal-dehydebe and Friedlander condensation with o-aminobenzaldehyde, followed by bromination with N-bromosuccinimide （NBS） to give compound 3. The SN2 reaction of compound 3 with N-substituted- piperazine 5a-5p yielded a series of ethyl 2-（substituted-piperazin-1-ylmethyl）-quinoline-3-carboxylate derivatives 6a-6p. The structures of the title compounds 6a-6p were characterized by elemental analysis, IR, ^1H NMR, ^13C NMR and MS techniques. The compound 6n was confirmed by X-ray single crystal diffraction analysis.