中文摘要：

几新奇 chiral 硫安类药剂 ligands 基于(1R,2S,4R,5S )-1,4-diamino-2,5-dimethylcyclohexane 骨骼被综合了，他们在到醛的 diethylzinc 的 enantioselective 增加的申请面对 Ti (OiPr ) 被调查 4。ligands，温度和 ligands 的装载数量的效果被学习。在优化条件下面，有各种各样的芳基醛和脂肪族的醛的 diethylzinc 的 enantioselective 增加顺利继续了并且负担得起 chiral 在多达 88% ee 的第二等的白酒。

英文摘要：

Several novel chiral sulfonamide ligands based on （1R,2S,4R,5S）-1,4-diamino-2,5-dimethylcyclohexane skele- ton have been synthesized and their application in the enantioselective addition of diethylzinc to aldehydes was in- vestigated in the presence of Ti（Oipr）4. The effect of ligands, temperature and the loading amount of ligands was studied. Under optimized conditions, enantioselective addition of diethylzinc with various aryl aldehydes and aliphatic aldehydes proceeded smoothly and afforded chiral secondary alcohols in up to 88% ee.