中文摘要：

目的：探讨广西新发现肝癌高发点乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）感染在肝癌家族聚集性中的作用。方法：在广西新发现的肝癌高发点选择发生2例以上肝癌病例的高发家族成员作为研究对象,并选择性别和年龄构成相同的无癌家族成员作为对照,应用ELISA法检测HBV和HCV血清学标志物,采用PCR和RT-PCR技术对HBVDNA和HCVRNA进行检测。结果：在肝癌高发家族和无癌家族两组成员中HBsAg、HBsAb、HBeAg、HBVDNA的阳性率分别为24.47%、35.11%、8.51%、14.89%和8.51%、53.19%、4.26%、4.26%,HBsAg、HBsAb和HBVDNA在两组间存在显著性差别,P值分别为0.003、0.012、0.013;而HBeAg在两组间无显著性统计学意义（P〉0.05）;两组均未发现HCV-Ab和HCVRNA阳性者。结论：广西新肝癌高发点的肝癌家族聚集性的主要危险因素可能是HBV的感染和遗传因素的共同作用;HCV的感染与此高发点的家族聚集性无关。

英文摘要：

Objectives To investigate the relationship between the infection of hepatitis B and C virus and the family clustering of hepatocellular carcinoma in the area with high mortality of hepatocellular carcinoma discovered recently in Guangxi region. Methods The subjests that whoes families had two or even more cases of hepatocelllular carcinoma, and whoes families hadn′t any cancer in the families were tested the serological marks of hepatitis B and C, such as HBsAg, HBsAb, HBeAg, HBVDNA, anti-HCV and HCVRNA with ELISA, RT-PCR and PCR respectively. Results The positive rates of HBsAg, HBsAb, HBeAg and HBVDNA were 24.47%, 35.11%, 8.51%, 14.89% and 8.51%, 53.19%, 4.26%, 4.26% in the subjests that whoes families had two or even more cases of hepatocelllular carcinoma and whoes families hadn′t any cancer in the families respectively. There were significant differences between the positive rates of HBsAg, HBsAb and HBVDNA in the two groups （P = 0.003, 0.012, 0.013）, but no significant difference between the positive rate of HBeAg in the two groups（P 0.05）. HCV-Ab and HCVRNA were negative in the two groups. Conclusions The risk factors in the development of family clustering of hepatocellular carcinoma may be the infection and replication of hepatitis B virus as well as genetics factor. HCV has no connection with the family clustering of hepatocellular carcinoma in the Area with high mortality of hepatocellular carcinoma discovered recently in Guangxi region.