中文摘要：

胰腺癌（ Pancreatic adenocarcinoma ，PAC）由于发病因素多、病情隐匿不易诊断、对放化疗不敏感而导致预后极差。细胞凋亡信号通路阻断可能是导致胰腺癌对传统放化疗不敏感的关键原因。本综述拟梳理胰腺癌细胞内部凋亡失衡主要信号通路，总结细胞凋亡诱导关键信号通路等在胰腺癌治疗中的基础研究进展，以期为拓展胰腺癌细胞凋亡的理解和开发凋亡相关靶向分子治疗提供新思路。

英文摘要：

Pancreatic adenocarcinoma （ PAC） is still a refractory human digest malignancies due to multi-faceted causes ,late diagnosis and insensitive to traditional chemo -and radio-therapy .Resistance to apoptosis could be one of the most relevant mechanisms for PAC to escape any non -surgical therapy .This review aims to clear up the main deregulated apoptosis signal pathways over the years and to find out the abnormal molecule tar -get（s）,and therefore,provide novel concepts for PAC molecular targeting therapy .