中文摘要：

根据RGD序列肽的构效关系,设计并合成了一系列以5-氨基-1,3-二氢-1,3-二氧-异吲哚-2-丙酸为分子骨架的新化合物.其中间体和目标物的化学结构经1H NMR,MS和元素分析确证.体外初步生物活性筛选结果表明,目标物在10-5mol/L浓度下对bFGF诱导的鸡胚绒毛尿囊膜新生血管生成有显著抑制活性.

英文摘要：

Based on the structure-activity relationships of RGD-containing peptides, a series of novel 5-amino-1,3-dihydro-1,3-dioxo-isoindole derivatives were designed and synthesized. The intermediates and target compounds were characterized by IH NMR, MS spectra and elemental analysis. Their ability to inhibit angiogenesis was evaluated in the chick embryo chorioaUantoic membrane assay at 10^-5 mol/L. Some compounds displayed obviously antiangiogenic activity induced by basic fibroblast growth factor.