中文摘要：

为研究条斑紫菜（Porphyra yezoensis）的抗高血压作用,用不同方式制备其提取物后灌胃给予自发性高血压大鼠（spontaneously hypertensive rats,SHR）和血压正常的Wistar大鼠,监测颈总动脉血压变化情况。结果显示：条斑紫菜水提物和醇提物均无显著降压作用,而其胃蛋白酶酶解物、中性蛋白酶酶解物均具有一定程度的降压作用,且对心率及血压正常的Wistar大鼠血压无不良影响。与血管紧张素转换酶抑制剂卡托普利相比,降压作用的大小顺序为卡托普利〉中性蛋白酶酶解物〉胃蛋白酶酶解物。表明条斑紫菜蛋白经中性蛋白酶和胃蛋白酶酶解后产生的活性肽具有高血压改善作用。

英文摘要：

In order to investigate the anti-hypertensive effects of various extracts from purple laver（Porphyra yezoensis）,spontaneously hypertensive rats（SHR） administered with extracts from purple laver by intragastric infusion and the change in blood pressure（BP） of the rats was monitored by carotid artery catherization.The results showed that water and ethanol extracts from purple laver had no effect on BP in SHR,but neutral protease and pepsin hydrlysates of purple laver had a significant BP-lowering effect.No adverse effect on heart rate and BP in normotensive Wistar-Kyoto rats was observed.The decreasing sequence of BP-lowering effect of the neutral protease and pepsin hydrlysates and captopril was found as follows：captoprilneutral protease hydrolysatepepsin hydrolysate.Based on this study,it could be concluded that peptides derived from neutral protease or pepsin hydrolysis of purple laver protein have an anti-hypertensive effect in SHR.