中文摘要：

目的将在胃的癌症前期的损害(GPL ) 上调查 Weining 小粒的临床的效果。有 GPL 的 120 个病人随机在 1:1 比率被分配收到 Weining 小粒(试用组) 或比较仪 Weifuchun 药片(控制组) 6 个月的方法。结果在包括的二个组之间被比较：全面反应；gastroscopically 坚定的反应；病理地证实的反应；Helicobacter pylori (HP ) 的根除；在胃的 mucosa 的 microvessel 密度(MVD ) ；脉管的 endothelial 生长因素(VEGF ) 的表示；interleukin 2 (IL-2 ) ；interleukin 6 (IL-6 ) ；T 淋巴细胞子集；免疫球蛋白；症状分数；生活(QOL ) 的质量；并且不利反应。在试用组的结果病人有一显著地更高(P < 0.05 ) 全面反应率(81.7%) 作为与那些相比在控制组(63.3%) 。相对有有 Weining 的 Weifuchun 药片治疗的治疗，小粒导致了重要改进(P < 0.05 ) 在为在 hypochondrium，和厌食的胃的疼痛，扩张和不通风的分数。当与药片相比小粒与显著地更高的全面 gastroscopically 坚定的回答被联系，评价(78.3% ；P < 0.05 ) 。织物样品的病理学的检查显示收到小粒的 61.7% 病人与 75.5% 的全面反应率被治好；这些率比在控制组显著地高(P < 0.05 ) 。与收到药片的病人比较，给小粒的那些是显著地，可能有他们的 HP 的更多根除了(75.0% 对 51.4% ；P < 0.05 ) 。在 MVD， VEGF， CD4 + ， CD4 +/CD8 + ， IL-2， IL-6 和 IgG 的改进比与 Weifuchun 药片与 Weining 小粒是显著地更大的(P < 0.05 或 P < 0.01 ) 。在 1 年的后续以后，在试用的 17.5% 病人在控制组作为与 39.5% 相比组织 relapsed (P < 0.05 ) 。相对控制组，试用组在物理、心理、社会的关系中，并且在环境领域显示出显著地更大的改进(P < 0.05 或 P < 0.01 ) 。没有重要不利反应在治疗期间被观察。Weining 小粒看起来在改进胃的癌症前期的状态和主要症状有效在禁止 angiogenesis，并且在减少 1 年的恶化，提高有免疫力的功能和 QOL 的?

英文摘要：

OBJECTIVE：To investigate the clinical effects of Weining Granules on gastric precancerous lesions（GPLs）.METHODS：120 patients with GPLs were randomly assigned in a 1：1 ratio to receive Weining Granules（trial group） or the comparator Weifuchun tablets（control group） for 6 months.Outcomes were compared between the two groups including：overall response;gastroscopically-determined response;pathologically-confirmed response;eradication of Helicobacter pylori（HP）;microvessel density（MVD） in the gastric mucosa;expression of vascular endothelial growth factor（VEGF）;interleukin 2（IL-2）;interleukin 6（IL-6）;T lymphocyte subsets;immunoglobulins;symptom scores;quality of life（QOL）;and adverse reactions.RESULTS：Patients in the trial group had a significantly higher（P〈0.05） overall response rate（81.7%） as compared with those in the control group（63.3%）.Relative to treatment with Weifuchun tablets treatment with Weining Granules resulted in a significant improvement（P〈0.05） in the scores for gastric pain,distension and stuffiness in the hypochondrium,and anorexia.As compared with the tablets the Granules were associated with a significantly higher overall gastroscopically-determined response rate（78.3%;P〈0.05）.Pathological examination of tissue samples indicated that 61.7% of patients receiving the granules were cured with an overall response rate of 75.5%;these rates were significantly higher than in the control group（P〈0.05）.In comparison with patients receiving the tablets,those given the granules were significantly more likely to have their HP eradicated（75.0% vs.51.4%;P〈0.05）.Improvements in MVD,VEGF,CD4＋,CD4＋/CD8＋,IL-2,IL-6 and IgG were significantly greater with the Weining Granules than with the Weifuchun tablets（P〈0.05 or P〈0.01）.After follow-up of 1 year,17.5% of patients in the trial group relapsed as compared with 39.5% in the control group（P〈0.05）.Relative to the control group,the trial group showed significantly g