中文摘要：

目的将在 cholangiocarcinoma 调查不正常的蛋白质激酶 C1 子类型(aPKC-1 ) 和 E-cadherin 的表情，并且分析侵略的分子的机制和 cholangiocarcinoma 的转移。在良性的胆汁管纸巾的 9 个标本和 cholangiocarcinoma 的 35 个标本的 aPKC-1 和 E-cadherin 的表情被检测由的方法想象免疫组织化学，并且他们到临床病理特征和 cholangiocarcinoma 的侵略的关联被分析。结果 aPKC-1 的积极的率比在良性的胆汁管纸巾在 cholangiocarcinoma 是显著地更高的(68.6% 对 11.1% ， P = 0.006 ) 当 E-cadherin 的积极的率比在良性的胆汁管纸巾在 cholangiocarcinoma 是显著地更低的时(37.1% 对 88.9% ， P = 0.016 ) 。aPKC-1 表示否定地被相关到 E-cadherin 表示(r =? 0.287， P 【 0.05 ) 。aPKC-1 表示是断然并且 E-cadherin 表示否定地被相关到 cholangiocarcinoma 的区别和侵略(P 【 0.05 ) 。aPKC-1 和 E-cadherin 的表情可以反映区别和 cholangiocarcinoma 的侵略潜力的结论。作为极的联系规定的蛋白质， aPKC-1 可以在 cholangiocarcinoma 的侵略和转移起一个重要作用。

英文摘要：

Objective： To investigate the expressions of atypical protein kinase C = subtype （aPKC-I and E-cadherin in cholangiocarcinoma, and analyze molecular mechanisms of the invasion and metastasis of cholangiocarcinoma. Methods： The expressions of aPKC-I nd E-cadherin in 9 specimens of benign bile duct tissues and 35 specimens of cholangiocarcinoma were detected by EnVision immunohistochemistry, and their correlations to the clinicopathologic characteristics and invasion of cholangiocarcinoma were analyzed. Results： The positive rate of aPKC-I was significantly higher in cholangiocarcinoma than in benign bile duct tissues （68.6% vs. 11.1%, P = 0.006）, while the positive rate of E-cadherin was significantly lower in cholangiocarcinoma than in benign bile duct tissues （37.1% vs. 88.9%, P = 0.016）. aPKC-I expression was negatively correlated to E-cadherin expression （r = -0.287, P 〈 0.05）. aPKC-I expression was positively and E-cadherin expression was negatively correlated to the differentiation and invasion of cholangiocarcinoma （P 〈 0.05）. Conclusion： The expressions of aPKC-I and E-cadherin may reflect the differentiation and invasive potential of cholangiocarcinoma. As a polar regulation-associated protein, aPKC-I may play an important role in the invasion and metastasis of cholangiocarcinoma.