改进了合成5.氨基-5,6,7,8.四氢.2(1H)喹啉酮(5)的方法。以环己二酮为原料,通过亚胺化,Miehad反应-环化反应,成肟反应和碱性条件下镍铝合金催化还原共四步反应合成了5,总收率19.6%,其结构经^1H NMR,IR和MS确证。
The synthesis method for 5-amine-5,6,7,8-tetrahydro-2 (1H) quinolinone ( 5 ) was improved. 5 in total yield of 19.6% was simply prepared from 1,3-cyclohexadione (1) by a four-step reaction of imination, Michael reaction-intermolecular cyclization and oximation, followed by reduction in the presense of Ni-Al alloy catalyst under alkali condition. The structure was characterized by ^1H NMR, IR and MS.