中文摘要：

目的 通过视（口形）-听（声音）联合刺激的事件相关电位（ERP）的研究,结合脑地形图分析,探讨视-听联合刺激的皮层处理相互关系。方法 收集正常青年志愿者19名,年龄22-30岁,予行标准刺激（元音[a]）和变异刺激（元音[i]）的视-听联合刺激及单独视觉、单独听觉刺激ERP检查。比较三种刺激条件下诱出的ERP的差异。结果 视-听联合标准刺激能诱发视觉刺激N1波和N2以及听觉刺激在600ms左右出现的正向波（P1波）。视-听联合刺激与单纯视觉刺激诱出的波形一致性较好,潜伏期、波幅均无显著差异。但视-听联合刺激的听觉P1波较单纯听觉刺激P1波的波幅减弱（P=0.04）,且脑地形图显示视-听联合刺激的听觉P1波分布向视觉中枢靠近。结论 视觉刺激对同意义听觉反应有抑制作用,且相关视觉刺激能使听觉刺激激活的区域向视觉靠近,提示在听觉康复训练过程中,可能避免视觉刺激（唇读）的康复效果更佳,但相关的研究需要进一步的深入。

英文摘要：

Objective This study is to investigate the interaction in visual and auditory cortical process- ing, through audiovisual stimulus ERP combined with topomapping and source analysis. Methods Nineteen normal young volunteers were recruited, aged from 22-30 years. All the subjects undertook audiovisual （vowel [a] vs. vowel [i]）, as well as visual and auditory ERP tests. ERP waves under different stimuli were compared. Results Audiovisual stimuli evoked visual N1 and N2, and also a positive wave at about 600 ms. Visu- al stimulus evoked ERPs were consistent with the visual part of responses to auditory visual stimuli. Howev- er, P1 amplitude evoked by audiovisual stimuli was lower than that evoked by auditory stimuli alone （p= 0.04）, and topomapping showed that its distribution was close to the visual cortex. Conclusions Related visu- al stimuli appear to inhibit auditory responses, and cause the auditory response active areas to shift toward the visual response area. The results suggest that in the process of hearing rehabilitation training, avoiding visual stimuli （lip reading） may improve outcomes, although further research is very much needed.