中文摘要：

目的将与血壅滞症候群(BSS ) 调查冠的心疾病(CHD ) 的内在的 metabolomic profifiling。方法 CHD 模型被一个 nameroid 缩窄器在中国缩小的猪劝诱。十五头缩小的猪随机被划分成一个模型组(n=9 ) 和一个控制组(n=6 ) ，分别地根据 arandom 数字桌子。在 4 个星期以后，血浆 hemorheology 被自动 hemorheological 分析器，包括分血器的索引，血浆粘性，血粘性，刚硬索引和红血球沉积率检测；心脏的功能被 echocardiograph 估计检测左室的结束收缩的直径(LVED ) ，左室的结束心脏舒张的直径(LVEDd ) ，喷射部分(EF ) ，部分弄短(FS ) 并且另外的指示物。煤气的层析结合了集体 spectrometry (GCMS ) ，生物信息学被使用与 BSS 分析 CHD 血浆的系列。结果 hemorheology 分析的结果在粘性显示出 signifificant 变化，与低砍更低的整个血粘性和在模型更高的血浆粘性与控制组相比组织。而且，整个血减小粘性在高砍率和整个血减小粘性在低砍 signifificantly 增加的率(P < 0.05 ) 。echocardiograph 结果表明了那心脏的 EF， FS 显示出 signifificant 差别(P < 0.05 ) ，与 EF，价值正在被减少到 50% 或更少的。GCMS 数据证明主要部件分析能清楚地在控制组从那些用 BSS 分开动物。基因和染色体的充实的京都百科全书生物小径结果建议包含的模式与精力新陈代谢包括的机能障碍被联系葡萄糖和类脂化合物混乱特别在 glycolysis/gluconeogenesis，半乳糖新陈代谢和 adenosine-triphosphate-binding 盒子 transporters。结论葡萄糖新陈代谢和类脂化合物新陈代谢混乱是到有 BSS 的 CHD 的症候群 classifification 的主要贡献者。

英文摘要：

Objective： To investigate the underlying metabolomic profiling of coronary heart disease（CHD） with blood stasis syndrome（BSS）. Methods： CHD model was induced by a nameroid constrictor in Chinese miniature swine. Fifteen miniature swine were randomly divided into a model group（n=9） and a control group（n=6）, respectively according to arandom number table. After 4 weeks, plasma hemorheology was detected by automatic hemorheological analyzer, indices including hematocrit, plasma viscosity, blood viscosity, rigidity index and erythrocyte sedimentation rate; cardiac function was assessed by echocardiograph to detect left ventricular end-systolic diameter（LVED）, left ventricular end-diastolic diameter（LVEDd）, ejection fraction（EF）, fractional shortening（FS） and other indicators. Gas chromatography coupled with mass spectrometry（GC-MS） and bioinformatics were applied to analyze spectra of CHD plasma with BSS. Results： The results of hemorheology analysis showed significant changes in viscosity, with low shear whole blood viscosity being lower and plasma viscosity higher in the model group compared with the control group. Moreover, whole blood reduction viscosity at high shear rate and whole blood reduction viscosity at low shear rate increased significantly（P〈0.05）. The echocardiograph results demonstrated that cardiac EF and FS showed significant difference（P〈0.05）, with EF values being decreased to 50% or less. The GC-MS data showed that principal component analysis can clearly separate the animals with BSS from those in the control group. The enriched Kyoto Encyclopedia of Genes and Genomes biological pathways results suggested that the patterns involved were associated with dysfunction of energy metabolism including glucose and lipid disorders, especially in glycolysis/gluconeogenesis, galactose metabolism and adenosine-triphosphate-binding cassette transporters. Conclusion： Glucose metabolism and lipid metabolism disorders were the major contributors to the syn