中文摘要：

建立以羧甲基-β-环糊精（CM-β-CD）和离子液体三甲基羟乙基双三氟甲磺酰亚胺盐（HOEtN1,1,1NTf2）共同作为手性选择剂,用于分离西酞普兰对映体的毛细管电泳法。采用未涂层熔融石英毛细管柱,考察CM-β-CD的质量浓度、HOEt N1,1,1NTf2的浓度、背景缓冲液的浓度及其pH和分离电压对拆分西酞普兰对映体的影响。在20 mmol/L磷酸盐缓冲液（pH 6.8）中添加15 g/L CM-β-CD和40 mmol/L HOEtN1,1,1NTf2,分离电压为15 kV、检测波长210 nm、高差10 cm、进样10 s的条件下,西酞普兰对映体在16 min内获得了基线分离,分离度为1.70。实验结果表明,CM-β-CD和离子液体HOEtN1,1,1NTf2联用能够提高西酞普兰对映体的分离度。

英文摘要：

To establish a capillary electrophoresis method for chiral separation of citalopram enantiomers, with carboxymethyl-β-cyclodextrin （CM-β-CD） and trimethyl-hydroxyethyl bis （trifluoromethylsulfonyl） imide （ HOEtN1,1,1 NTf2 ） as the chiral selectors. The influences of concentration of CM-β-CD,ionic liquid, concentration and pH of buffer solution, separation voltage on chiral separation were investigated. The enantiomers of citalopram was completely separated in 20 mmol/L Na2 HPO4-H3 PO4 buffer solution of pH 6. 8 containing 40 mmol/L HOEtN1,1,1NTf2 and 15 g/L CM-/3-CD,the applied voltage was 15 kV,the detection wavelength was 210 nm and the sampling time was 10 s. The baseline separation was achieved for citalopram enantiomers within 16 min,attaining the degree of resolution of 1.70.