中文摘要：

目的：建立一种测定依巴斯汀含量的新方法。方法：用光谱法研究依巴斯汀、水杨基荧光酮及1-丁基-3-甲基咪唑四氟硼酸盐（C4）间的相互作用。利用在pH6.5的醋酸缓冲体系中,依巴斯汀与水杨基荧光酮反应能形成稳定的化合物,且C4离子液体对其具有增敏作用,该物质在560 nm波长处有最大吸收,且其吸光度与依巴斯汀浓度在一定范围内存在定量关系,建立了测定依巴斯汀含量的新方法。结果：在优化条件下,线性方程为：A=0.029＋0.005C（C,μg·mL^-1,r=0.9995,检出限为0.96μg·mL^-1S/N=3）,线性范围为2.5～20.0μg·mL^-1,回收率为96.1%～106.4%。结论：本法快速准确,简便易行,适用于依巴斯汀片中依巴斯汀含量的测定。

英文摘要：

Objective：To establish a method for the determination of ebastine （EBS）. Method：The interaction of EBS, salicyl fluorine （SAF） and 1 - butyl - 3 - methylimidazolium tetrafluoroborate （ C4 ） was studied by spectro-photometry. It showed a steady compound was formed through the interaction of EBS and SAF in the acetic acid buffer system （ pH = 6.5 ） and the interaction could be sensitized by C4. The compound had a maximum absorption at 560 nm and there was a good linear relationship between the absorbance of the compound and a certain concen-tration range of ebastine concentration. Results ： The equation of calibration curve was A = 0. 029 ＋ 0. 005 C （ C ： μg·mL^-1 ）. The range of calibration curve was between 2. 5 and 20. 0 μg·mL^-1 （ r = 0. 9995 ） and the detection limit was 0. 96 μg·mL^-1（ S/N = 3 ）. The recovery was 96. 1% - 106. 4%. Conclusion： The method is simple, rap-id with good accuracy for determining ebastine.