中文摘要：

本研究首先通过SAS9．1分析2093头北京地区中国荷斯坦牛体细胞数（SCC）的变化规律，依据SCC将牛只划分为乳房炎易感牛（Case）及抗性牛（Contr01）；再基于Case-control设计进行全基因组关联分析。通过染色体水平的Bonferroni校正，共检测到6个SNPs与乳房炎易感性及抗性显著相关。其中19号染色体检测出的显著SNP（ARS-BFGI，NGS-78516，P-5．20065e-05）在其200kb范围内共有3个基因（PRKRIP1、ARHGAP23和TBX21）与炎症反应密切相关。研究结果为奶牛乳房炎易感性及抗性的分子遗传基础研究提供了数据。

英文摘要：

Abstract.. The variation trends of somatic cell count （SCC） were analyzed using SAS 9.1. According to the SCC data, in 2 093 Chinese Holsteins in Beijing all of the cows were divided into two groups, mastitis susceptive cows （case） and resistant cows （control）. Based on case-control de- sign, genome-wide association study was further performed. The results showed that six SNPs were significantly relevant to mastitis susceptibility or resistance after Bonferroni adjusting on the chromosome level. Three genes （PRKRIP1, ARHGAP23, TBX21） on BTA19 closely related to inflammation response were discovered near the significant SNP （ARS-BFGL-NGS-78516, P = 5.20e-05） within 200 kb. The results provide fundamental data for molecular genetics of mastitis resistance in dairy cattle.