中文摘要：

目的了解冠心病患者血清胆红素水平与冠状动脉狭窄程度问的关系，评估血清胆红素预测冠状动脉狭窄严重程度的可能性。方法采用Gensini评分系统，将48例经皮冠状动脉介入治疗的冠心病患者分为冠心病轻度病变组、冠心病重度病变组。选取同期住院的25例非冠心病患者作为对照组，检测人选者血清总胆红素（TBIL）、直接胆红素（DBIL）、间接胆红素（IBIL）水平。结果对照组的TBIL为（16．81±5．87）μmol／L，DBIL为（6．28±2．68）μmol／L，IBIL为（12．14±2．78）μmol／L。冠心病轻度病变组的TBIL为（13．81±3．62）μmol／L，DBIL为（4．83±1．28）μmol／L，IBIL为（8．99±3．20）μmol／L。冠心病重度病变组的TBIL为（9．79±3．39）ixmol／L，DBIL为（3．46±1．50）txmol／L，IBIL为（5．934-2．45）μmol／L。与对照组相比，冠心病组TBIL、DBIL、IBIL降低（P〈0．05）。重度病变组TBIL、DBIL、IBIL水平较轻度病变组降低（P〈0．05）。TBIL与Gensini评分呈负相关（r=-0．3816，P〈0．01），IBIL与Gensini评分呈负相关（r=-0．4006，P〈0．01），血管病变支数与Gensini评分正相关（r=0．647，P〈0．01）。结论BIL与冠脉狭窄程度负向相关，BIL可作为冠脉狭窄程度的预测因子。

英文摘要：

Objective To investigate the relationship between serum bilirubin and coronary artery stenosis degree in the coronary artery disease patients（CAD）. Methods According to Gensini marking system ,48 percutaneous coronary inter- vention CAD patients were divided into 2 groups as CAD mild lesion group and CAD severe lesion group. Additional 25 non-CAD hospitalized patients in the corresponding period were selected as control group. The serum total bilirubin （TBIL） , direct bilirubin（DBIL） , and indirect bilirubin （IBIL） were examined. Results In the control group, TBIL was （ 16.81 ＋ 5.87 ） μmol/L, DBIL was （ 6.28 ± 2.68 ） μmol/L, and IBIL was （ 12.14 ± 2.78 ） μmol/L. In the CAD mild lesion group,TBIL was （ 13.81 ± 3.62） μmol/L, DBIL was （4.83 ± 1.28 ） μmol/L, and IBIL was （ 8.99 ± 3.20） μmol/L. In the CAD severe lesion group, TB1L was （9.79 ± 3.39 ） μmol/L, DBIL was （ 3.46 ± 1.50） μmol/L, and IBIL was （ 5.93 ± 2.45 ） μmol/L. Serum TBIL, DBIL and IBIL numerical of CAD group were significantly lower than those of control group, the differences were statistically significant（ P 〈 0.05 ）. Serum TBIL, DBIL and IBIL numerical of CAD se- vere lesion group were significantly lower than those of CAD mild lesion group, the differences were also statistically signif- icant （ P 〈 0.05 ）. There was a negative correlation between TBIL, IBIL and Gensini grade （ TBIL： r = - 0.3816, P 〈 0.01 ; IBIL：r = -0.4006 ,P 〈 0.01 ）. There was a positive correlation between vaseulopathy and Gensini grade（ r = 0.647, P 〈 O. O1 ）. Conclusion Serum bilirubin level was significantly associated with coronary stenosis degree. The higher the coro- nary stenosis degree was, the lower the serum bilirubin level was. Serum bilirubin could be acted as the prediction index of the coronary stenosis degree.