中文摘要：

姜黄素（curcumin）是植物姜黄（curcuma）的主要有效成分,常用于食物天然色素及调味品,具有广泛的药理作用。近年来的研究发现,姜黄素除了具有抗氧化和抗炎等药理作用外,细胞和动物模型实验结果显示它具有抗肿瘤及预防癌变的药理作用[1]。人体的-期和Ⅱ期临床实验结果也表明,姜黄素对肿瘤的防治有较好的活性,同时肿瘤患者对姜黄素具

英文摘要：

The effect of curcumin on JAK-STAT signaling pathway was investigated in hepatoma cell lines Huh7 and Hep3B. Curcumin inhibited cell proliferation and induced apoptosis of both cell lines, but Huh7 cells were more sensitive to curcumin than Hep3B cells. Curcumin （50 μmol.L^-1） significantly increased phosphorylations of p38 （T180/Y182） and STAT-1 （S727） in Huh7 and Hep3B cells, and caused relocalization of phosphorylated-STAT-1 （Y701） from cytoplasm to nucleus in Hep3B cells. In addition, curcumin （25 and 50 μmol.L^-1） dramatically suppressed the phosphorylation level of STAT-1 （Y701） and resulted in a significant reduction of nuclear phosphorylated-STAT- 1 （Y701） in Huh7 cells.